Year: 2024 Title: EMPACT-MI Subtitle: Empagliflozin after Acute Myocardial Infarction Type of Trial: A double-blind, randomized, placebo-controlled trial Objective: To assess if the use of empagliflozin in the treatment of acute myocardial infarction (AMI) affects future mortality or heart failure … Read More
Author Archives: admin
STEP-HFpEF DM: Semaglutide in HFpEF and DM
The study suggests that Semaglutide is effective in reducing symptoms and weight in patients with obesity-related heart failure with preserved ejection fraction and type 2 diabetes when compared to a placebo
ACORN Trial: Cefepime vs. Piperacillin-Tazobactam
The ACORN Trial: Cefepime vs. Piperacillin-Tazobactam’s Impact on Renal Outcomes In 2023, the ACORN Trial set out to investigate the renal and neurological outcomes of hospitalized adults with acute infections treated with two common antibiotics, providing valuable insights for healthcare … Read More
RESCUE-ASDH: Craniotomy vs. Decompressive Craniectomy
The RESCUE-ASDH Trial: Craniotomy vs. Decompressive Craniectomy The RESCUE-ASDH Trial, conducted in 2023, was a multicenter, randomized, controlled trial that played a crucial role in understanding the management of acute subdural hematoma (ASDH), a severe brain injury. Objective of the … Read More
PACER Trial: Platelet Transfusion before CVC Placement
The PACER Trial: Revisiting Platelet Transfusions for CVC Placement The 2023 PACER Trial investigated a critical aspect of clinical care involving patients with thrombocytopenia undergoing central venous catheter (CVC) placement. This parallel, single-blinded, randomized controlled trial aimed to establish whether … Read More
CARTITUDE-4: Cilta-cel in Multiple Myeloma
The CARTITUDE-4 Trial: Groundbreaking Treatment for Multiple Myeloma The CARTITUDE-4 Trial, a pivotal study published in 2023, represents a significant advancement in the treatment of multiple myeloma, particularly for patients with lenalidomide-refractory disease. This Phase 3 randomized, open-label trial assessed … Read More
CAPItello-291: Capivasertib in Breast Cancer
The CAPItello-291 Trial: A New Horizon in Breast Cancer Treatment The CAPItello-291 Trial, a Phase III double-blind randomized trial conducted in 2023, has significantly contributed to the evolving landscape of breast cancer treatment, particularly for hormone receptor-positive advanced cases. Objective … Read More
BUCKLED Trial: US vs. XRay in Peds Forearm Fractures
The BUCKLED Trial: Ultrasound vs. Radiography in Pediatric Forearm Fractures In 2023, the BUCKLED Trial offered a novel perspective on diagnosing pediatric distal forearm fractures. This multicenter, open-label, noninferiority, randomized trial investigated whether ultrasonography could stand as a viable alternative … Read More
Baby-OSCAR: Ibuprofen in PDA
The Baby-OSCAR Trial: Evaluating Ibuprofen in Preterm Infants with PDA In 2024, the Baby-OSCAR Trial emerged as a pivotal study examining the effects of early treatment of patent ductus arteriosus (PDA) with ibuprofen in extremely preterm infants. This randomized, double-blind, … Read More
AGENT IDE: Paclitaxel-Coated Balloon for ISR
The AGENT IDE Trial: Revolutionizing the Treatment of In-Stent Restenosis The AGENT IDE Trial, a prominent study published in 2024, has shed light on a pivotal question in cardiology: Is a paclitaxel-coated balloon more effective than an uncoated balloon for … Read More