Author Archives: admin

SMART-MED Trial Summary: Balanced Crystalloids versus Saline in Critically Ill

2018 SMART-MED & SMART-SURG TRIAL Balanced crystalloids versus saline in critically ill adults Pragmatic, unblinded, cluster-randomized, multiple-crossover trial Objective: To determine whether administration of balanced crystalloids reduce a 30 day composite outcome of death, new renal replacement therapy or persistent … Read More

PARTNER Trial Summary: Family-Support Intervention in ICU

2018 PARTNER TRIAL A Randomized trial of a Family-support intervention in intensive care units Multicenter, stepped-wedge, cluster-randomized trial Objective: To compare a multicomponent family-support intervention delivered by the interprofessional ICU team with usual care 1420 Inclusion criteria: Patients >18 years … Read More

REVIVE Trial Summary: Exercise Program in Critically Ill after Discharge

2017 REVIVE TRIAL Effectiveness of an exercise programme on physical function in patients discharged from hospital following critical illness. | Multicentre, prospective phase II, randomised controlled trial Objective: To investigate the effectiveness of a 6 week exercise programme in patients … Read More

REDUCE DELIRIUM Trial Summary: Haloperidol in Critically Ill at High Risk of Delirium

2017 2017 REDUCE-DELIRIUM TRIAL M Effect of haloperidol on survival among critically ill adults with a high risk of delirium | Randomized, double-blind, placebo-controlled trial Objective: To determine survival with prophylactic use of haloperidol among critically ill adults at high … Read More

PRECISE Trial Summary: Pregabalin for Acute and Chronic Sciatica

2017 PRECISE TRIAL Trial of pregabalin for acute and chronic sciatica Randomized, double-blind, placebo-controlled trial Objective: To determine whether pregabalin reduces the intensity of sciatica as compared to placebo 209 Inclusion criteria: Sciatica patients aged > 18 years having: – … Read More

POLAR Trial Summary: Prophylactic Hypothermia in Severe Traumatic Brain Injury

2018 POLAR TRIAL Prophylactic hypothermia for severe traumatic brain injury Multicentre, partially-blinded, randomised controlled trial Objective: To determine the effectiveness of early prophylactic hypothermia compared with normothermic management of patients after severe traumatic brain injury 511 patients Inclusion criteria: Intubated … Read More

POKER Trial Summary: Propofol or Ketofol for Procedural Sedation

2016 POKER TRIAL Propofol or Ketofol for procedural sedation and analgesia in emergency medicine Randomised, double-blind clinical trial Objective: To determine whether an emergency physician-provided deep sedation with 1:1 combination of ketamine & propofol (ketofol) resulted in fewer adverse respiratory … Read More

PLUS Trial Summary: Balanced Multielectrolyte Solution in Critically Ill

2022 PLUS TRIAL Balanced multi electrolyte solution versus saline in critically ill adults Investigator initiated, double-blind, parallel-group, randomised controlled trial d a Objective: To assess whether the use of balanced multielectrolyte solution (BMES) in preference to 0.9% sodium chloride solution … Read More

IPASS Trial Summary: Gefitinib or Carboplatin-Paclitaxel in Pulmonary Adenocarcinoma

2009 IPASS TRIAL Gefitinib or Carboplatin-Paclitaxel in Pulmonary Adenocarcinoma phase 3, multicenter, open-label, parallel-group, randomised controlled trial d a Objective: To assess the effect of gefitinib as compared with carboplatin-paclitaxel for adenocarcinoma of the lung in nonsmokers or former light … Read More

SHoC-ED Trial Summary: POCUS in ER for Hypotension

2018 SHOC-ED TRIAL M Does point-of-care ultrasonography improve clinical outcomes in emergency department patients with undifferentiated hypotension? International, multicenter, randomized controlled trial Objective: To determine whether a standardised point-of-care D ultrasound (POCUS) protocol, compared with usual care, improves 30 day … Read More