2015 CATCH TRIAL Tinzaparin vs warfarin for treatment of acute venous thromboembolism in patients with active cancer phase 3, multinational, open-label, randomized controlled trial Objective: To assess the efficacy and safety of tinzaparin vs warfarin for treatment of acute, symptomatic … Read More
Cardiovascular Disease
COACH Trial Summary: Access to Care in Heart Failure
2022 COACH TRIAL Trial of an intervention to improve acute heart failure outcomes cross-sectional, cluster-randomized trial M Objective: To determine the effectiveness of systematic use of a hospital-based point-of-care tool to support clinical decision-making, followed by rapid follow-up in an … Read More
DCP Trial Summary: HCTZ vs Chlorthalidone
2022 DCP TRIAL Chlorthalidone compared with hydrochlorothiazide for the preven- tion of cardiovascular events in patients with hypertension: The Diuretic Comparison Project (DCP) Open-label, pragmatic, randomized controlled trial Objective: To compare the differences between hydrochlorothiazide (HCTZ) compared with chlorthalidone in … Read More
UNIVERSAL Trial Summary: US-Guided Femoral Access
2022 UNIVERSAL TRIAL Routine ultrasonography guidance for femoral vascular access for cardiac procedures multicenter, randomized controlled trial Objective: To determine whether routinely using ultrasonography guidance for femoral arterial access for coronary angiography/intervention reduces bleeding or vascular complications 621 Patients Inclusion … Read More
TIME Trial Summary: Morning vs. Evening dose of Antihypertensives
2022 TIME TRIAL Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK prospective, open-label, blinded-endpoint, randomized controlled trial IM Objective: To compare the major cardiovascular outcomes of evening dosing of antihypertensive medication … Read More
Surgical Ablation of AFib with MV Surgery
2015 SURGICAL ABLATION OF ATRIAL FIBRILLATION TRIAL Surgical ablation of atrial fibrillation during mitral-valve surgery parallel, randomized controlled trial M Objective: To evaluate treatment with mitral valve surgery plus ablation compared with mitral valve surgery alone among patients with mitral … Read More
SUPPORT Trial Summary: Olmesartan in CHF
2015 SUPPORT TRIAL M Clinical impacts of additive use of olmesartan in hypertensive patients with chronic heart failure (CHF) prospective, open-label, randomized controlled trial Objective: to examine whether an additive treatment with an ARB, olmesartan, reduces the mortality and morbidity … Read More
SIMPLE Trial Summary: ICD Implantation without VFib Induction
2015 SIMPLE TRIAL Cardioverter defibrillator implantation without induction of ventricular fibrillation multicentre, single-blind, non-inferiority, randomized controlled trial M Objective: To compare the efficacy & safety of ICD implantation without defibrillation testing versus the standard of ICD implantation with defibrillation testing … Read More
SERVE HF Trial Summary: Adaptive sero-ventilation for CSA in HF
2015 SERVE-HF TRIAL M Adaptive servo-ventilation for central sleep apnea in systolic heart failure parallel, randomized controlled trial Objective: To assess the effectiveness of adaptive servo-ventilation Damong subjects with heart failure with reduced ejection fraction and central sleep apnea 1315 … Read More
SECURE PCI Trial Summary: Loading Atorvastatin in ACS
2018 SECURE-PCI TRIAL Effect of loading dose of atorvastatin prior to planned percutaneous coronary intervention on major adverse cardiovascular events in acute coronary syndrome double-blind, multicenter, randomized controlled trial Objective: To determine if periprocedural loading doses of atorvastatin decrease 30-day … Read More