2022 BOX TRIAL: BP TARGETS IN OHCA Blood-pressure targets in comatose survivors of cardiac arrest Investigator-initiated, double-blind, superiority, 2×2 factorial design, randomized clinical trial Objective: To evaluate the appropriate blood pressure target in comatose survivors of out-of-hospital cardiac arrest 789 … Read More
Critical Care
SMART-MED Trial Summary: Balanced Crystalloids versus Saline in Critically Ill
2018 SMART-MED & SMART-SURG TRIAL Balanced crystalloids versus saline in critically ill adults Pragmatic, unblinded, cluster-randomized, multiple-crossover trial Objective: To determine whether administration of balanced crystalloids reduce a 30 day composite outcome of death, new renal replacement therapy or persistent … Read More
PARTNER Trial Summary: Family-Support Intervention in ICU
2018 PARTNER TRIAL A Randomized trial of a Family-support intervention in intensive care units Multicenter, stepped-wedge, cluster-randomized trial Objective: To compare a multicomponent family-support intervention delivered by the interprofessional ICU team with usual care 1420 Inclusion criteria: Patients >18 years … Read More
REVIVE Trial Summary: Exercise Program in Critically Ill after Discharge
2017 REVIVE TRIAL Effectiveness of an exercise programme on physical function in patients discharged from hospital following critical illness. | Multicentre, prospective phase II, randomised controlled trial Objective: To investigate the effectiveness of a 6 week exercise programme in patients … Read More
REDUCE DELIRIUM Trial Summary: Haloperidol in Critically Ill at High Risk of Delirium
2017 2017 REDUCE-DELIRIUM TRIAL M Effect of haloperidol on survival among critically ill adults with a high risk of delirium | Randomized, double-blind, placebo-controlled trial Objective: To determine survival with prophylactic use of haloperidol among critically ill adults at high … Read More
PLUS Trial Summary: Balanced Multielectrolyte Solution in Critically Ill
2022 PLUS TRIAL Balanced multi electrolyte solution versus saline in critically ill adults Investigator initiated, double-blind, parallel-group, randomised controlled trial d a Objective: To assess whether the use of balanced multielectrolyte solution (BMES) in preference to 0.9% sodium chloride solution … Read More
TTM 48 Trial Summary: TTM for 48 hours in Cardiac Arrest
2017 2017 TTM 48 TRIAL M Targeted Temperature Management for 48 vs 24 hours and neurologic outcome after out-of-Hospital Cardiac Arrest (OOHCA) Multicenter,blinded,parallel,pragmatic,randomized superiority trial Objective: To determine neurologic outcomes with Targeted Temperature Management (TTM) at 33°C for 48 hours … Read More
ATESS Trial Summary: Vitamin C + Thiamine for Septic Shock
2020 ATESS TRIAL Combination therapy of vitamin C and thiamine for septic shock Multicentre, double-blind, randomized controlled trial Objective: To evaluate the effects of early combination therapy with intravenous vitamin C and thiamine on recovery from organ failure in patients … Read More
PSP Trial Summary: Interventional Treatment for Spontaneous Pneumothorax
2020 PSP TRIAL M Conservative versus interventional treatment for spontaneous pneumothorax Prospective, randomized control, non-inferiority trial Objective: To assess whether conservative management compared to interventional treatment results in acceptable rates of lung re-expansion at 8 weeks in patients with primary … Read More
FIESTY Trial Summary: Fibrinogen in Severe Trauma
2021 FEISTY TRIAL Fibrinogen early in severe trauma study | multicentre, randomized controlled pilot study s Objective: To compare the time to fibrinogen replacement using f ibrinogen concentrate (FC) or cryoprecipitate (Cryo) in severely injured trauma patients with major hemorrhage … Read More