2021 2021 VITAMINS TRIAL M Effect of Vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock Open label, multi-centre, randomized, phase IIb clinical trial Objective: To investigate whether … Read More
Critical Care
ARREST Trial: ECMO-facilitated Resuscitation in Refractory Cardiac Arrest
2020 ARREST 2020 TRIAL M Advanced reperfusion strategies for patients with out-of hospital cardiac arrest (OHCA) and refractory ventricular fibrillation (VF) Phase 2, single center, open-label, randomized clinical trial Objective: To compare implementation of early ECMO facilitated resuscitation compared to … Read More
ANTHARTIC Trial Summary: Prevention of Ventilator-Associated Pneumonia after Cardiac Arrest
2019 ANTHARTIC TRIAL M Prevention of early Ventilator-Associated Pneumonia after cardiac arrest Multicentre, randomised, double-blind, placebo-controlled Objective: To investigate whether in post out-of-hospital cardiac arrest (OOHCA) patients treated with targeted temperature management, does the use of empirical antibiotics prevent early … Read More
NONSEDA Trial Summary: Sedation in Critically Ill Intubated Patients
2020 NONSEDA TRIAL M Nonsedation or light sedation in critically ill, mechanically ventilated patients Investigator-initiated, randomised, clinical, parallel-group, multinational, superiority trial . a 5 Objective: To assess whether in critically ill, mechanically ventilated patients, does a strategy of no sedation, … Read More
PEPTIC Trial Summary: PPI vs. H2 blockers for Stress Ulcers in Intubated Patients
2020 PEPTIC TRIAL Effect of stress ulcer prophylaxis with Proton pump inhibitors vs Histamine-2 receptor blockers on in-hospital mortality among ICU patients receiving invasive mechanical ventilation Pragmatic, open-label, cluster randomised crossover design trial Objective: To compare in-hospital mortality rates using … Read More
VAM-IHCA Trial Summary: Vasopressin and Methylprednisolone on ROSC after Cardiac Arrest
2021 VAM-IHCA TRIAL M Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients with In-Hospital Cardiac Arrest Multicenter, randomized, double-blind, placebo-controlled trial Objective: To determine whether the combination of vasopressin and methylprednisolone administered during in-hospital … Read More
CHECK-UP Trial Summary: Ramped vs Sniffing Position for Intubation
2017 CHECK-UP: POSITION- Ramped position vs Sniffing position during endotracheal intubation of critically ill adults 2 x 2 factorial design,randomised, multicentre,pragmatic trial 9 5 Objective: To evaluate the reduction in incidence of oxygen desaturation in ramped position as compared to … Read More
MIDAS Trial Summary: Midodrine for Vasopressor Weaning
2020 MIDAS TRIAL: Effect of midodrine versus placebo on time to vasopressor discontinuation in patients with persistent hypotension in the intensive care unit Multi-centre, randomised, double-blind, placebo-controlled trial Objective: To investigate whether the administration of midodrine, an oral al-adrenergic agonist, … Read More
EAT-ICU Trial Summary: Early Goal-Directed Nutrition in ICU Patients
2017 EAT-ICU TRIAL: Early goal-directed nutrition versus standard of care in adult intensive care patients Single centre, blinded, randomised controlled trial Objective: To evaluate the effects of early goal-directed nutrition (EGDN) vs. standard nutritional care in adult ICU patients. 203 … Read More
EPICC Trial Summary: Intensive Physical Rehabilitation in Critically ill
2017 EPICC TRIAL Intensive versus standard physical rehabilitation therapy in the critically illl parallel-group, assessor-blinded, randomized controlled trial Objective: To determine improvement in long-term clinical outcomes with Increased intensity ICU-based physical rehabilitation therapy as compared with standard therapy. 308 Inclusion … Read More