WOMAN Trial: The Use of Tranexamic Acid in Reducing Death Due to Post-Partum Haemorrhage Post-partum haemorrhage (PPH) is a leading cause of maternal mortality worldwide. The administration of tranexamic acid has been shown to decrease bleeding-related deaths in trauma patients. A recent trial aimed to assess the impact of early tranexamic acid administration on death, […]
Category: Ob/Gyn
AGE Trial Summary: Mammogram Screening for Breast Cancer
AGE: Effect of mammographic screening from age 40 years on breast cancer mortality Multicenter, open label randomized comparative trial Objective: To assess if initiation of breast cancer screening with mammograms at age 40-41 reduces breast cancer mortality Women age 39-41 receiving care by a primary care 160,840 doctor associated with a study center were randomized […]
WOMAN Trail Summary: Early tranexamic acid in post-partum hemorrhage
2018 WOMAN TRIAL Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage Randomised, double-blind, placebo-controlled trial Objective: To determine whether early administration of tranexamic acid reduces death from bleeding in women with post-partum haemorrhage as compared with placebo 5 20,060 Inclusion criteria: Women aged 216 years with […]
CHAP Trial Summary: Chronic Hypertension in Pregnancy
2022 CHAP TRIAL Treatment for Mild Chronic Hypertension during Pregnancy Open-label, multicenter, randomized trial Objective: To assess if treating mild chronic hypertension during pregnancy with a BP goal of <140/90 mmHg would lower incidence of adverse maternal and perinatal outcomes than a strategy of withholding treatment until the BP was 160/105 mm Hg or higher […]