ATESS Trial Summary: Vitamin C + Thiamine for Septic Shock
2020 ATESS TRIAL Combination therapy of vitamin C and thiamine for septic shock Multicentre, double-blind, randomized controlled trial Objective: To evaluate the effects of early...
PSP Trial Summary: Interventional Treatment for Spontaneous Pneumothorax
2020 PSP TRIAL M Conservative versus interventional treatment for spontaneous pneumothorax Prospective, randomized control, non-inferiority trial Objective: To assess whether conservative management compared to interventional...
FIESTY Trial Summary: Fibrinogen in Severe Trauma
2021 FEISTY TRIAL Fibrinogen early in severe trauma study | multicentre, randomized controlled pilot study s Objective: To compare the time to fibrinogen replacement using...
COBI Trial Summary: Hypertonic Saline in Traumatic Brain Injury
2021 COBI TRIAL M Effect of continuous infusion of hypertonic saline vs standard care on 6-month neurological outcomes in patients with traumatic brain injury multicenter,...
LOCO2 Trial Summary: Oxygen Therapy in ARDS
2020 2020 LOCO2 TRIAL M Liberal or conservative oxygen therapy for Acute Respiratory Distress Syndrome Multicentre, randomised controlled trial Objective: To assess whether in patients...
VITAMINS Trial: Vitamin C, hydrocortisone, and thiamine in Septic Shock
2021 2021 VITAMINS TRIAL M Effect of Vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients...
ARREST Trial: ECMO-facilitated Resuscitation in Refractory Cardiac Arrest
2020 ARREST 2020 TRIAL M Advanced reperfusion strategies for patients with out-of hospital cardiac arrest (OHCA) and refractory ventricular fibrillation (VF) Phase 2, single center,...
SURMOUNT-1 Trial: Tirzepatide for Weight Loss in Obesity
2022 SURMOUNT-1 TRIAL M Tirze patide Once Weekly for the Treatment of Obesity Phase 3 double-blind, randomized, controlled trial Objective: To assess the efficacy and...
MR CLEAN-NO IV Trial Summary: IV Alteplase before Endovascular Therapy in Stroke
2021 MR CLEAN-NO IV TRIAL M 2021 A Randomized Trial of Intravenous Alteplase before Endovascular Treatment(EVT) for Stroke investigator-initiated, international, multicenter, prospective, randomized, open-label trial...
KEYNOTE-826 Trial Summary: Pembrolizumab in Metastatic Cervical Cancer
2021 KEYNOTE-826 TRIAL Pembrolizumab for Persistent, Recurrent, or Metastatic Cervical Cancer double-blind, phase 3, randomized controlled trial Objective: To assess whether adding pembrolizumab to platinum-based...