Hypertension remains a major global health issue, particularly for patients whose blood pressure remains uncontrolled despite multiple medications. The Advance-HTN trial, presented at ACC.25 in Chicago in 2025, provides compelling evidence for the use of lorundrostat, a novel aldosterone synthase … Read More
resistant hypertension
AMBER Trial: Patiromer to Allow Spironolactone use in Resistant Hypertension
Resistant hypertension poses a significant challenge, especially in patients with chronic kidney disease (CKD). The AMBER trial emerges as a beacon of hope, evaluating the role of the potassium binder patiromer in enabling the use of spironolactone in this difficult-to-treat … Read More
Landmark Clinical Trials of Aldosterone Antagonists
landmark clinical trials focusing on aldosterone antagonists (mineralocorticoid receptor antagonists) like spironolactone and eplerenone, which are commonly used in heart failure and other conditions: 1. RALES (1999) • Title: Randomized Aldactone Evaluation Study • Focus: Heart failure with reduced ejection … Read More