2019
ANTHARTIC TRIAL M
Prevention of early Ventilator-Associated
Pneumonia after cardiac arrest
Multicentre, randomised, double-blind, placebo-controlled
Objective: To investigate whether in post out-of-hospital cardiac arrest (OOHCA) patients treated with targeted temperature management, does the use of empirical antibiotics prevent early ventilator-associated pneumonia.
194 patients
Inclusion criteria: Patients ≥ 18 years of age hospitalized in the ICU after OOHCA with shockable rhythm,& treated with targeted temperature management of 32 to 34°C
Antibiotic Group (N=99)
19
PRIMARY OUTCOME
Control Group
(N=95)
Rate of early ventilator-associated pneumonia %
HR 0.55; 95% CI, 0.31 to 0.92; P=0.003
SECONDARY OUTCOME
34
34
4
Rate of late VAP %
5
4
Urinary tract infection %
3
Conclusion: A 2-day course of antibiotic therapy with amoxicillin- clavulanate in patients receiving a 32-to-34°C targeted temperature management strategy after out-of-hospital cardiac arrest with initial shockable rhythm resulted in a lower incidence of early ventilator- associated pneumonia than placebo.
B François et al. NEJM 2019;381:1831-42
