Aortic Stenosis Severity Algorithm (ACC/AHA 2020 Guidelines) Step 1: Assess Aortic Valve Morphology and Function Step 2: Quantify AS Severity (Echocardiographic Parameters) Severity AVA (cm²) Mean Gradient (mmHg) Peak Velocity (m/s) Dimensionless Index (DI) Mild >1.5 <20 <3.0 >0.5 Moderate … Read More
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IVUS-ACS Trial: Intravascular Ultrasound vs. Angiography for PCI in Acute Coronary Syndromes
IVUS-ACS Trial Summary Introduction In the management of acute coronary syndrome (ACS), optimal guidance for percutaneous coronary intervention (PCI) remains a critical factor in improving patient outcomes. The IVUS-ACS trial, a large, multicenter, randomized study, investigates whether intravascular ultrasound (IVUS)-guided … Read More
ADAPT-Sepsis Trial: PCT vs. CRP-Guided Antibiotic Duration
Understanding the ADAPT-Sepsis Trial: PCT vs. CRP-Guided Antibiotic Duration Sepsis remains a critical challenge in intensive care units (ICUs), often requiring prolonged antibiotic use. The ADAPT-Sepsis trial, published in JAMA (2024), aimed to determine whether procalcitonin (PCT)-guided or C-reactive protein … Read More
VT vs. SVT with Abberation Infographic
VT vs SVT with Aberration: A Quick Interpretation Guide Introduction Distinguishing ventricular tachycardia (VT) vs supraventricular tachycardia (SVT) with aberrancy is a critical skill in electrophysiology and emergency medicine. Misdiagnosis can lead to inappropriate treatment and adverse outcomes. This blog … Read More
CHANCE-3 Trial: Colchicine in Acute Stroke
Colchicine for Stroke Prevention (CHANCE-3 Trial) 📍 Study Type: Randomized, placebo-controlled trial🏥 Setting: 244 hospitals in China👥 Participants: 8,343 patients (age ≥40) with minor/moderate ischemic stroke or TIA & hs-CRP ≥2 mg/L Intervention vs. Control 💊 Colchicine Group (n=4,176)• 0.5 … Read More
SURMOUNT 3 Trial: Tirzepatide in Obesity
Visual Abstract Summary: SURMOUNT-3 Phase 3 Trial Objective: To evaluate the efficacy and safety of tirzepatide, a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, in achieving additional weight loss in adults with overweight or obesity who … Read More
HEAL-HOA Trial: volunteering among lonely older adults
Objective: To assess the effects of structured social volunteering over 12 months on loneliness among older adults during the COVID-19 pandemic. Study Design: Findings: 📉 Volunteering significantly reduced loneliness at 6 months (T2) compared to control: ⚠️ Most benefits were … Read More
TIME Trial: Evening versus morning dosing of usual antihypertensives
TIME StudyHypertension Treatment in Morning versus Evening Objective:To determine whether evening dosing of antihypertensive medication improves major cardiovascular outcomes compared to morning dosing in patients with hypertension. Study Design: Participants: Primary Endpoint: Results: Conclusion:Evening dosing of antihypertensive medication did not … Read More
POST-TNK Trial: Intra-Arterial Tenecteplase in Acute Stroke
Visual Summary of POST-TNK Trial Objective:To evaluate the efficacy and safety of intra-arterial tenecteplase in patients with large vessel occlusion stroke achieving near-complete to complete reperfusion after EVT. Design & Participants: Interventions:Patients were randomized into two groups: Primary Outcome:Freedom from … Read More
STOPDAPT-2 ACS: Clopidogrel Monotherapy after ACS
Visual Abstract Summary for the STOPDAPT-2 ACS Trial Question Is 1–2 months of dual antiplatelet therapy (DAPT) followed by clopidogrel monotherapy noninferior to 12 months of DAPT with aspirin and clopidogrel in patients with acute coronary syndromes (ACS)? Design Key … Read More