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VIOLET Trial: High-Dose Vitamin D3 for Critically Ill

VIOLET Trial Summary The VIOLET trial was a phase 3, randomized, double-blind, placebo-controlled study designed to evaluate the effects of early vitamin D3 supplementation in critically ill patients with vitamin D deficiency who were at high risk for death. Vitamin D deficiency is a common and potentially reversible factor contributing to morbidity and mortality in […]

VISION Trial: Lutetium-177–PSMA-617 for Metastatic Prostate Cancer

The VISION trial was a phase 3 international, open-label study that aimed to evaluate the efficacy of Lutetium-177 (177Lu)–PSMA-617, a radioligand therapy, in patients with metastatic castration-resistant prostate cancer (mCRPC). This type of cancer remains fatal despite recent advancements, and prostate-specific membrane antigen (PSMA) is highly expressed in mCRPC. The trial enrolled patients who had […]

VITAL-AF Trial: Screening for AFib

VITAL-AF Trial Summary The VITAL-AF trial aimed to determine whether point-of-care screening with a handheld single-lead ECG device during primary care visits increases the diagnosis of atrial fibrillation (AF) in older adults. The study randomized 16 primary care clinics in a 1:1 ratio, with half implementing AF screening using the AliveCor KardiaMobile device during vital […]

VITAL-DEP Trial: vitamin D and omega-3 FA for depression

VITAL-DEP Trial Summary The VITAL-DEP trial aimed to investigate whether long-term supplementation with vitamin D3 could prevent depression in the general adult population. The study included 18,353 adults aged 50 years or older without depression or clinically relevant depressive symptoms at the beginning of the trial. The participants were randomly assigned to receive either vitamin […]

TAME Trial: Mild Hypercapnia after Cardiac Arrest

TAME Trial Summary The TAME trial investigated the impact of mild hypercapnia versus normocapnia on neurologic outcomes in adults with coma who were resuscitated after out-of-hospital cardiac arrest. Current guidelines recommend normocapnia, but mild hypercapnia has been suggested to enhance cerebral blood flow and potentially improve neurologic outcomes. The trial randomly assigned adults admitted to […]

DEVICE Trial: Video versus Direct Laryngoscopy for Tracheal Intubation

DEVICE Trial Summary The article discusses the findings of the DEVICE trial, which aimed to determine whether video laryngoscopy increased the likelihood of successful tracheal intubation on the first attempt compared to direct laryngoscopy in critically ill adults. The trial was conducted at 17 emergency departments and intensive care units (ICUs), involving a multicenter, randomized […]

TRAVERSE Trial: CV Safety of Testosterone-Replacement Therapy

TRAVERSE Trial Summary The abstract highlights the findings of the TRAVERSE trial, which aimed to assess the cardiovascular safety of testosterone-replacement therapy in middle-aged and older men with hypogonadism. The trial sought to determine whether testosterone replacement therapy in this population increased the risk of cardiovascular events. The inclusion criteria for participants required them to […]

CONVINCE Trial: Hemodiafiltration or Hemodialysis in Kidney Failure

CONVINCE Trial Summary The abstract discusses the results of the CONVINCE trial, a randomized, controlled study comparing high-dose hemodiafiltration (HDF) with conventional high-flux hemodialysis (HD) in patients with end-stage kidney disease (ESKD). The trial aimed to determine whether high-dose HDF reduces the risk of death in ESKD patients compared to high-flux HD. Previous studies had […]