AVATAR Trial Summary: AVR in Asymptomatic Severe Aortic Stenosis

AVATAR Trial AVR aortic stenosis

2021 AVATAR TRIAL M Aortic Valve replacement versus Conservative treatment in asymptomatic severe Aortic Stenosis Parallel, Randomised controlled trial Objective: To evaluate aortic valve replacement (AVR) compared with conservative therapy among patients with asymptomatic severe aortic stenosis 157 Inclusion criteria: Patients 18 years of age with asymptomatic severe aortic stenosis (asymptomatic status confirmed by exercise testing) & Society of Thoracic Surgeons-Predicted Risk of Mortality (STS-PROM) score <8% patients Early surgery group(n=78) Conservative therapy group (n=79) PRIMARY OUTCOME 15.2 All-cause death % HR 0.46; 95% CI, 0.23 to 0.90; P=0.02 34.7 SECONDARY OUTCOME Thirty-day mortality % OR 0.34; 95% CI, 0.02 to 5.61 9.5 Heart failure hospitalization % HR 0.32; 95% CI, 0.08 to 1.19 20.1 Conclusion: Among patients with asymptomatic severe aortic stenosis, early surgery was beneficial. Early surgery compared with conservative therapy was associated with a significantly lower incidence of composite adverse events over a median follow-up of 32 months. M Banovic et al. CIRCULATIONAHA.121.057639

Comments are closed.