2010 EARLY PALLIATIVE CARE M Early Palliative Care for Patients with Metastatic Non-Small-cell Lung Cancer Single-center, Prospective, non-blinded, parallel-group, randomized, control Objective: In patients with metastatic NSCLC, how does the early introduction of palliative care affect the quality of life? 151 patients Inclusion Criteria: Ambulatory Patients with pathologic diagnosis of NSCLC in prior 8 weeks. ECOG performance status 0-2. Early palliative care (N=77) Standard Care (N=74) PRIMARY OUTCOME 2.3 Trial Outcome Index (TOM) (difference between groups 4.6, 95% CI, 0.2 to 8.9, P=0.04) -2.3 SECONDARY OUTCOME 11.6 Median Survival (months) (HR 1.7, 95% CI 1.14-2.54, p=0.02) 8.9 53 Documentation of Resuscitation Preferences (%) P=0.05 28 Aggressive end-of-life care (%) P=0.05 54 Conclusion: Early integration of palliative care improved quality of life, reduced aggressive care at the end of life, and improved survival among patients with metastatic NSCLC. Temel JSet al. NEJM. 2010;363(8):733-742. Summary by Kiriti S. Vattikonda DO