ANDROMEDA SHOCK Trial: Resuscitation in Septic Shock

andromeda shock trial septic
ANDROMEDA-SHOCK: Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels in Septic Shock Multicenter, randomized trial conducted at 28 intensive care units in 5 countries 424 patients with septic shock were randomized to to a step-by-step resuscitation protocol aimed at: 000 normalizing capillary refill time (n=212) normalizing or decreasing lactate levels (n=212) Primary Outcome median overall survival 34.9% HR 0.75 [95% CI, 0.55 to 1.02]; 43.4% 5.6 P = 0.06 Secondary Outcome organ dysfunction at 72 hours based on mean SOFA scores difference, -1.00, 95% CI, -1.97 to -0.02; P = .045 ICU and hospital length of stay No difference renal replacement therapy and vasopressor-free days No difference 6.6 Among patients with septic shock, a resuscitation strategy targeting normalization of capillary refill time, compared with a strategy targeting serum lactate levels, did not reduce all-cause 28-day mortality. Hernández G et al. JAMA. 2019 Feb 19;321(7):654-664. M Visualmed


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