Explore the pivotal clinical trials that have shaped our understanding of the role of steroids in the management of septic shock, unveiling the complexities and nuances of this controversial topic. Introduction Septic shock is a life-threatening condition characterized by a dysregulated host response to infection, leading to circulatory and metabolic abnormalities. The use of steroids […]
Tag: sepsis
ANDROMEDA SHOCK Trial: Resuscitation in Septic Shock
ANDROMEDA-SHOCK: Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels in Septic Shock Multicenter, randomized trial conducted at 28 intensive care units in 5 countries 424 patients with septic shock were randomized to to a step-by-step resuscitation protocol aimed at: 000 normalizing capillary refill time (n=212) normalizing or decreasing lactate levels […]
VICTAS Trial: Vitamin C, Thiamine, and Hydrocortisone in Sepsis
2021 VICTAS TRIAL IM Effect of vitamin C, thiamine, and hydrocortisone on ventilator-and vasopressor-free days in patients with sepsis multicenter, double-blind, randomized controlled trial Objective: To determine whether combination of vitamin C, thiamine & hydrocortisone every 6 hours increases ventilator- and vasopressor-free days compared with placebo in patients with sepsis. 501 Patients Inclusion criteria: Patients […]
ALBIOS Trial Summary: Albumin in Septic Shock
ALBUMIN REPLACEMENT IN PATIENTS WITH SEVERE SEPSIS OR SEPTIC SHOCK – THE ALBIOS TRIAL Multicenter, open-label, randomized trial Patients with severe sepsis 1,818 or septic shock were randomized to Albumin to maintain serum albumin ≥3 g/dL vs (n=910) No albumin (n=908) Mean follow-up: 90 Days PRIMARY OUTCOMES 31.8% All-cause mortality at 28 days P=0.94 41.1% […]
ADRENAL Trial Summary: Steroids in Septic Shock
ADJUNCTIVE GLUCOCORTICOID THERAPY IN PATIENTS WITH SEPTIC SHOCK – THE ADRENAL TRIAL Multicenter, double-blind, parallel-group, randomized, controlled trial 3,658 patients with septic shock requiring vasopressors and mechanical ventilation were randomized to VS Hydrocortisone Placebo (n=1,832) (n=1,826) Mean follow-up: 90 Days PRIMARY OUTCOMES 27.9% Death from Any Cause at 90 Days 28.8% 3 P=0.50 © SECONDARY […]
ACTS Trial: Ascorbic acid, Steroids and Thiamine in Septic Shock
2020 ACTS TRIAL Effect of ascorbic acid, corticosteroids, and thiamine on organ injury in septic shock Multicenter, randomized, blinded, placebo-controlled superiority trial M Objective: To determine whether the combination of ascorbic acid, corticosteroids, and thiamine attenuates organ injury in patients with septic shock. 205 patients Inclusion criteria: Patients ≥18 years of age with infection and […]
CLASSIC Trial Summary: Restriction of IVF in Septic Shock
2022 CLASSIC TRIAL Restriction of Intravenous Fluid in ICU Patients with Septic Shock Multicenter, international, randomized controlled trial ca Objective: To investigate whether the restriction of Intravenous Fluid in ICU Patients with Septic Shock improves 90-day survival? unipro 1554 Patients with septic shock in the ICU who had received at least 1 liter of IV […]
LOVIT Trial Summary: IV Vitamin C in Septic Shock
2022 LOVIT TRIAL Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit Randomized, placebo-controlled trial Objective: To assess the use of intravenous vitamin C in a dults with sepsis who were receiving vasopressor therapy in the intensive care unit (ICU) 872 patients 872 Inclusion Criteria: adults who had been in the ICU […]