2018 HIGH VS STANDARD CUTOFF HEMOFILTRATION IN AKI A Double-Blind RCT of High cutoff versus Standard Hemofiltration in critically ill patients with Acute Kidney Injury (AKI) Single-center, double-blind, randomized controlled trial Objective: To assess impact of High cutoff hemofilter versus a Standard hemofilter on the median hours of noradrenaline-free time at day 7 in critically ill AKI patients on noradrenaline for haemodynamic support 76 Inclusion criteria: – Patients aged >18 years on noradrenaline for hemodynamic support – Patients requiring CRRT for AKI patients Continuous Veno-venous Hemofiltration: High cutoff (n=38) Continuous Veno-venous Hemofiltration: Standard (n=38) PRIMARY OUTCOME Median hours of noradrenaline-free time at day 7 P= 0.520 56 SECONDARY OUTCOMES 55.6 In-hospital mortality % OR 2.49; 95% CI 0.81 to 7.66; P= 0.191 34.2 90 Median dose of IV albumin given (in grams) P= 0.252 80 Conclusion: In critically ill patients with acute kidney injury,continuous venovenous hemofiltration-high cutoff did not reduce the duration of vasopressor support or mortality or change albumin levels compared with continuous venovenous hemofiltration-standard. R Atan et al. Crit Care Med. 2018 Oct;46(10):e988-1994