ICE CUB 2 Trial Summary: Systematic ICU Triage in Critically Ill Patients

ICE CUB 2 trial summary, ICU mortality

2017 ICE-CUB 2 TRIAL : Effect of systematic intensive care unit triage on long-term mortality among critically ill elderly patients in France Multicenter,cluster-randomized clinical trial Objective: To determine reduction in 6-month mortality in critically ill elderly patients by recommending systematic ICU admission as compared with usual practice. 3037 patients Patients >75 years presenting to ED with predefined critical condition that potentially require organ support; preserved functional and nutritional status; free of active cancer. baoooo Systematic strategy group (n = 1519) Standard practice group (n = 1518) PRIMARY OUTCOME Death risk at 6 months % RR 1.16; 95% CI 1.07-1.26; P<0.001 SECONDARY OUTCOME ICU admission rate % RR 1.80; 95% CI 1.66-1.95 In-hospital mortality % RR 1.05; 95% CI, 0.96-1.14 Conclusion: The program to promote systematic ICU admission increased ICU use but did not reduce 6-month mortality among critically ill elderly patients in France. B.Guidet et al. JAMA 2017 Oct 17,318(15):1450-1459