Tag: ICU

DEVICE Trial: Video versus Direct Laryngoscopy for Tracheal Intubation

DEVICE Trial Summary The article discusses the findings of the DEVICE trial, which aimed to determine whether video laryngoscopy increased the likelihood of successful tracheal intubation on the first attempt compared to direct laryngoscopy in critically ill adults. The trial was conducted at 17 emergency departments and intensive care units (ICUs), involving a multicenter, randomized […]

SAFE Trial Summary: Albumin or Saline in ICU

2004 SAFE TRIAL A comparison of albumin and saline for fluid resuscitation in the intensive care unit multicenter, double-blind, randomized controlled trial M Objective: To compare the effect of fluid resuscitation with albumin as compared with saline on mortality in a heterogeneous population of patients in the ICU 6997 patients 目 Inclusion criteria: Patients ≥18 […]

ADRENAL Trial Summary: Steroids in Septic Shock

ADJUNCTIVE GLUCOCORTICOID THERAPY IN PATIENTS WITH SEPTIC SHOCK – THE ADRENAL TRIAL Multicenter, double-blind, parallel-group, randomized, controlled trial 3,658 patients with septic shock requiring vasopressors and mechanical ventilation were randomized to VS Hydrocortisone Placebo (n=1,832) (n=1,826) Mean follow-up: 90 Days PRIMARY OUTCOMES 27.9% Death from Any Cause at 90 Days 28.8% 3 P=0.50 © SECONDARY […]

ACURASYS Trial Summary: NM blockers in ARDS

2010 ACURASYS TRIAL Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome Multicenter, double-blinded, placebo-controlled trial Objective: To assess if administration of cisatracurium improve survival when compared to placebo in ICU patients undergoing mechanical ventilation for early severe ARDS 340 patients on mechanical ventilation for < 48 hours with ARDS (PaO2: FiO2 <150, PEEP ≥ 5cmH20 […]

3SITES Trial Summary: Central Venous Catheterization Insertion Site

2015 3SITES TRIAL Intravascular complications of central venous catheterization by insertion site Multicenter, randomized controlled trial Objective: To evaluate the risk of catheter related bloodstream infection or symptomatic catheter related deep-vein thrombosis in an adult patient who had been admitted to an ICU. 3027 Inclusion criteria: Age > 18 years, ICU admitted requiring central venous […]

BOX Trial Summary: Oxygen Targets in Comatose Survivors of Cardiac Arrest

2022 BOX TRIAL: OXYGEN TARGETS IN OHCA Oxygen targets in comatose survivors of cardiac arrest Investigator-initiated, open-label, superiority,2×2 factorial design, randomized clinical trial Objective: To evaluate the appropriate oxygen target for mechanical ventilation in comatose survivors of out-of-hospital cardiac arrest 789 Inclusion criteria: Adults >18 years admitted to the hospital after resuscitated cardiac arrest (of […]

SPARK Trial Summary: Furosemide in critically ill patients with early AKI

2017 SPARK TRIAL The effect of low-dose furosemide in critically illl patients with early acute kidney injury (AKI) Pilot, multicenter, randomized, double-blinded, placebo-controlled trial Objective: To evaluate the impact of furosemide in early AKI on worsening AKI, kidney recovery and RRT use as compared to placebo. 73 Patients > 18 years with RISK RIFLE category […]

PARTNER Trial Summary: Family-Support Intervention in ICU

2018 PARTNER TRIAL A Randomized trial of a Family-support intervention in intensive care units Multicenter, stepped-wedge, cluster-randomized trial Objective: To compare a multicomponent family-support intervention delivered by the interprofessional ICU team with usual care 1420 Inclusion criteria: Patients >18 years without decision-making capacity, with at least 1 of; Ventilated for > 4 days; an estimated […]

REVIVE Trial Summary: Exercise Program in Critically Ill after Discharge

2017 REVIVE TRIAL Effectiveness of an exercise programme on physical function in patients discharged from hospital following critical illness. | Multicentre, prospective phase II, randomised controlled trial Objective: To investigate the effectiveness of a 6 week exercise programme in patients discharged home following critical illness compared with standard care 60 patients Inclusion criteria: Critically ill […]

LOCO2 Trial Summary: Oxygen Therapy in ARDS

2020 2020 LOCO2 TRIAL M Liberal or conservative oxygen therapy for Acute Respiratory Distress Syndrome Multicentre, randomised controlled trial Objective: To assess whether in patients with Acute Respiratory Distress Syndrome (ARDS), does conservative (Target PaO2:55-70mmHg; SpO2: 88-92%) vs. liberal (Target PaO2:90-105mmHg; SpO2: 96%) oxygen reduce death at 28 days 201 patients Adults who were intubated […]