INPRESS Trial Summary: Blood Pressure Management in Patients Undergoing Major Surgery

INPRESS Trial summary, blood pressure for major surgery

2017 INPRESS TRIAL Effect of individualized vs standard blood pressure management strategies on postoperative organ dysfunction among high-risk patients undergoing major surgery. Multicenter, randomized, parallel-group clinical trial Objective: To evaluate reduction in post-op organ dysfunction with Pan individualized BP management strategy as compared to standard practice in high-risk patients undergoing surgical procedures. 5 298 Inclusion criteria: Patients >50 years of age: – Undergoing surgery under GA for >2hrs – ASA score > – Pre-op AKI Risk Index of class 3 patients Individualized treatment group (n=149) Standard treatment group (n=149) PRIMARY OUTCOME 38.1 Composite of SIRS & at least 1 organ system dysfunction by post op day 7 % RR 0.73; 95% CI, 0.56 to 0.94; P= 0.02 51.7 SECONDARY OUTCOME 32.7 Renal dysfunction % RR 0.70; 95% CI, 0.5 to 0.92; P= 0.01 49.0 5.4 Altered Consciousness % RR 0.34; 95% CI, 0.16 to 0.75; P= 0.007 15.9 Conclusion: Management targeting an individualized systolic BP reduced the risk of post-op organ dysfunction compared with standard management. E Futier et al. JAMA 2017,318(14):1346-1357