The RADIANCE-HTN TRIO trial, detailed in The Lancet in 2021, is another pivotal study in the domain of hypertension treatment, focusing on a challenging group of patients: those resistant to a standard triple combination pill. This trial delves into the … Read More
blood pressure
RADIANCE-HTN SOLO Trial: Renal Denervation in HTN
The RADIANCE-HTN SOLO trial, published in The Lancet in May 2018, marks a significant stride in hypertension treatment research. This trial focused on the safety and efficacy of a novel endovascular ultrasound renal denervation procedure compared to a sham procedure … Read More
INTERACT3 Trial: ICU care bundle in acute ICH
INTERACT3 Trial Summary Background: Methods: Findings: Primary Outcome: Interpretation: Trial Information: Key Takeaways: Source
ACCOMPLISH Trial: Benazepril + Amlodipine or HCTZ for Hypertension
2008 ACCOMPLISH TRIAL Benazepril plus Amlodipine or Hydrochlorothiazide for Hypertension in High-Risk Patients Multi-centered, double-blind, randomized, controlled trial Objective: To evaluate the effect of amlodipine vs. hydrochlorothiazide in patients with hypertension and at high risk for cardiovascular disease. E 11,506 … Read More
ACCORD BP Trial Summary: Intensive BP Control in Type 2 Diabetes
2010 ACCORD BP TRIAL Effects of intensive blood-pressure control in type 2 diabetes mellitus Multicenter, randomized, controlled, open-label trial Objective: In patients with T2DM at high risk for CV events, does intensive BP control (SBP <120 mmHg) reduce rates of … Read More
BOX Trial Summary: BP Target in OHCA
2022 BOX TRIAL: BP TARGETS IN OHCA Blood-pressure targets in comatose survivors of cardiac arrest Investigator-initiated, double-blind, superiority, 2×2 factorial design, randomized clinical trial Objective: To evaluate the appropriate blood pressure target in comatose survivors of out-of-hospital cardiac arrest 789 … Read More
INPRESS Trial Summary: Blood Pressure Management in Patients Undergoing Major Surgery
2017 INPRESS TRIAL Effect of individualized vs standard blood pressure management strategies on postoperative organ dysfunction among high-risk patients undergoing major surgery. Multicenter, randomized, parallel-group clinical trial Objective: To evaluate reduction in post-op organ dysfunction with Pan individualized BP management … Read More
CHAP Trial Summary: Chronic Hypertension in Pregnancy
2022 CHAP TRIAL Treatment for Mild Chronic Hypertension during Pregnancy Open-label, multicenter, randomized trial Objective: To assess if treating mild chronic hypertension during pregnancy with a BP goal of <140/90 mmHg would lower incidence of adverse maternal and perinatal outcomes … Read More