2016 POKER TRIAL Propofol or Ketofol for procedural sedation and analgesia in emergency medicine Randomised, double-blind clinical trial Objective: To determine whether an emergency physician-provided deep sedation with 1:1 combination of ketamine & propofol (ketofol) resulted in fewer adverse respiratory events requiring intervention than propofol alone for procedural sedation and analgesia 573 Inclusion criteria: Adult patients requiring deep procedural sedation to facilitate the performance of a painful procedure in the ED patients Ketofol (n=281) Propofol (n=292) PRIMARY OUTCOME Occurrence of an adverse respiratory event (desaturation, apnea, or hypoventilation) % Diff 2; 95% CI-2 to 5 SECONDARY OUTCOMES Incidence of Hypotension (BP< 90mmHg) % Diff 7; 95% CI 4 to 10 Emergence delirium % Diff 3; 95% CI 0.4 to 6 Conclusion: Ketofol and propofol resulted in a similar incidence of adverse respiratory events requiring intravenous sedation and analgesia. Also propofol resulted in more hypotension as compared to ketofol. I Ferguson et al. Ann Emerg Med. 2016 Nov;68(5):574-582.e1