SHENFU Trial Summary: Shenfu Injection After in hospital Cardiac Arrest

Shenfu injection trial after cardiac arrest

2017 SHENFU TRIAL Efficacy and safety of combination therapy of Shenfu injection and post-resuscitation bundle in patients with return of spontaneous circulation(ROSC) after in-hospital cardiac arrest Prospective,randomized controlled clinical study Objective:To evaluate the efficacy,safety & improvement in mortality of combined therapy of Shenfu injection & post-resuscitation care bundle among in-hospital cardiac arrest patients 978 patients Inclusion criteria: Patients >18 years of age with sustained return of spontaneous circulation (ROSC) following an in-hospital cardiac arrest Shenfu injection group (n=492) Control group (n=486) PRIMARY OUTCOME 42.7 28-day survival % NNT= 8; 95% CI 6.67 to 18.62; P=0.02 30.1 SECONDARY OUTCOME 39.6 90-day survival % P=0.001 25.9 8.6 Duration of Mechanical ventilation (in days) P<0.001 12.7 44.3 Multiple organ failure % P=0.01 53 Conclusion: Shenfu injection combined with post-resuscitation care bundle improves clinical outcomes in patients with ROSC after in-hospital cardiac arrest. Q Zhang et al. Crit Care Med. 2017 Oct;45(10):1587-1595 Summary by Dr. Shreyash Bhoyar, MBBS

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