TRANSFUSE Trial Summary: Age of RBCs for Transfusion in Critically Ill

Transfuse trial summary RBCs age

2017 TRANSFUSE TRIAL Age of red cells(RBC) for transfusion and outcomes in critically ill adults Multicenter, randomized, double-blind trial Objective: To determine the effects of duration of RBC storage on mortality after transfusion among critically ill adults. 4994 patients Inclusion criteria: Patients >18 years of age or older who were admitted to a participating ICU, who had an anticipated ICU stay of at least 24 hours & in whom the medical staff had decided to transfuse one or more red-cell units Short-term (11.8 days) storage (n=2490] Long-term (22.4 days) storage (n=2504] PRIMARY OUTCOME 24.8 90-day mortality % 90-days, Risk diff 0.7; 95%CI -1.7 to 3.1;P=0.57 180-days, Risk diff 0.4; 95%CI -2.1 to 3.0;P=0.75 24.1 SECONDARY OUTCOME 1.4 Febrile non-haemolytic transfusion reactions % RR 0.90; 95% CI 0.57 to 1.42; P= 0.65 1.6 23.3 28-Day Persistent Organ Dysfunction with death % P=0.39 Conclusion: The age of transfused RBC did not affect 90-day mortality among critically ill adults. DJ Cooper et al. NEJM.2017:377:1858-1867 | Summary by Dr. Shreyash Bhoyar, MBBS