The medical world is continually seeking innovative methods to combat and prevent life-threatening conditions. One such condition is ventilator-associated pneumonia, a severe complication that affects patients undergoing mechanical ventilation. The recent AMIKINHAL trial, a multicenter, double-blind, randomized, controlled, superiority study, … Read More
critically ill
VIOLET Trial: High-Dose Vitamin D3 for Critically Ill
VIOLET Trial Summary The VIOLET trial was a phase 3, randomized, double-blind, placebo-controlled study designed to evaluate the effects of early vitamin D3 supplementation in critically ill patients with vitamin D deficiency who were at high risk for death. Vitamin … Read More
DEVICE Trial: Video versus Direct Laryngoscopy for Tracheal Intubation
DEVICE Trial Summary The article discusses the findings of the DEVICE trial, which aimed to determine whether video laryngoscopy increased the likelihood of successful tracheal intubation on the first attempt compared to direct laryngoscopy in critically ill adults. The trial … Read More
65 Trial Summary: Vasopressors in Older Critically Ill Patients
2020 65 TRIAL Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Critically III patients Multicenter, pragmatic, randomized clinical trial Objective: To evaluate the effect on mortality at 90 days of reducing the exposure to vasopressors through permissive hypotension … Read More
3SITES Trial Summary: Central Venous Catheterization Insertion Site
2015 3SITES TRIAL Intravascular complications of central venous catheterization by insertion site Multicenter, randomized controlled trial Objective: To evaluate the risk of catheter related bloodstream infection or symptomatic catheter related deep-vein thrombosis in an adult patient who had been admitted … Read More
BOX Trial Summary: Oxygen Targets in Comatose Survivors of Cardiac Arrest
2022 BOX TRIAL: OXYGEN TARGETS IN OHCA Oxygen targets in comatose survivors of cardiac arrest Investigator-initiated, open-label, superiority,2×2 factorial design, randomized clinical trial Objective: To evaluate the appropriate oxygen target for mechanical ventilation in comatose survivors of out-of-hospital cardiac arrest … Read More
BOX Trial Summary: BP Target in OHCA
2022 BOX TRIAL: BP TARGETS IN OHCA Blood-pressure targets in comatose survivors of cardiac arrest Investigator-initiated, double-blind, superiority, 2×2 factorial design, randomized clinical trial Objective: To evaluate the appropriate blood pressure target in comatose survivors of out-of-hospital cardiac arrest 789 … Read More
SMART-MED Trial Summary: Balanced Crystalloids versus Saline in Critically Ill
2018 SMART-MED & SMART-SURG TRIAL Balanced crystalloids versus saline in critically ill adults Pragmatic, unblinded, cluster-randomized, multiple-crossover trial Objective: To determine whether administration of balanced crystalloids reduce a 30 day composite outcome of death, new renal replacement therapy or persistent … Read More
PARTNER Trial Summary: Family-Support Intervention in ICU
2018 PARTNER TRIAL A Randomized trial of a Family-support intervention in intensive care units Multicenter, stepped-wedge, cluster-randomized trial Objective: To compare a multicomponent family-support intervention delivered by the interprofessional ICU team with usual care 1420 Inclusion criteria: Patients >18 years … Read More
REVIVE Trial Summary: Exercise Program in Critically Ill after Discharge
2017 REVIVE TRIAL Effectiveness of an exercise programme on physical function in patients discharged from hospital following critical illness. | Multicentre, prospective phase II, randomised controlled trial Objective: To investigate the effectiveness of a 6 week exercise programme in patients … Read More