TRICOP Trial Summary: Transfusion strategy in critically ill Oncologic patients

tricop trial critically ill oncologic

2017 2017 TRICOP TRIAL Liberal vs restrictive transfusion strategy in critically ill oncologic patients: The transfusion requirements in critically ill oncologic Single-center, randomized, double-blind controlled trial Objective: To assess whether a restrictive strategy of RBC transfusion reduces 28-day mortality when compared with a liberal strategy in cancer patients with septic shock. E 157 Inclusion criteria: Cancer patients aged >18 years with septic shock in the first 6-hrs of ICU admission patients Liberal transfusion strategy (Hb threshold < 9 g/dL) (n=149] Restrictive transfusion strategy (Hb threshold < 7 g/dL) (n=151] PRIMARY OUTCOME 28-day mortality % HR 0.74; 95% CI 0.53 to 1.04; P=0.08 56 SECONDARY OUTCOMES 90-day mortality % HR 0.72; 95% CI 0.53 to 0.97; P=0.03 70 Hospital length of stay (in days) P=0.23 13 Conclusion: We observed a survival trend favoring a liberal transfusion strategy in patients with septic shock when compared with the restrictive strategy. FS Bergamin et al. Crit Care Med. 2017 May;45(5):766-773