UK TAVI Trial Summary: TAVI in Moderate Aortic Stenosis

UK TAVI aortic stenosis trial summary

2022 UK TAVI TRIAL M Effect of TAVI vs Surgical Aortic Valve Replacement on All-Cause Mortality in Patients With Aortic Stenosis Multicenter, randomized controlled trial – Objective: To assess if TAVI is non-inferior to surgical aortic valve replacement in patients aged 70 years or older with severe, symptomatic aortic stenosis and moderately increased operative risk? N=913 patients. Inclusion criteria: Patients aged 70 years or older with severe, symptomatic aortic stenosis and moderately increased operative risk due to age or comorbidity. TAVI (N=458) VS Surgery (N=455) PRIMARY OUTCOME 4.6 All-cause mortality at 1 year P<.001 for noninferiority 6.6 SECONDARY OUTCOME 7.2 Major bleeding events at 1 year % HR 0.33; 95% CI, 0.24 to 0.45 20.2 10.3 Vascular complications HR, 4.42; 95% CI, 2.54 to 7.71 2.4 14.2 Pacemaker implantation HR, 2.05; 95% CI, 1.43 to 2.94 7.3 Conclusion: Among patients aged 70 years or older with severe, symptomatic aortic stenosis and moderately increased operative risk, TAVI was noninferior to surgery with respect to all-cause mortality at 1 year. JAMA. 2022;327(19):1875-1887. doi:10.1001/jama.2022.5776 M Visualmed

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