Alcohol Abstinence in AFib Clinical Trial Summary

alcohol afib trial

2020 ALCOHOL ABSTINENCE IN ATRIAL FIBRILLATION multicenter, prospective, open-label, randomized, controlled trial Objective: To assess the effect of abstinence from alcohol on secondary prevention of atrial fibrillation 140 patients Inclusion criteria: age of 18 to 85 years, presence of symptomatic paroxysmal AF (≥2 episodes in the 6 months) or symptomatic persistent AF with a rhythm-control strategy, and regular alcohol consumption (≥10 drinks or~ 120 g of alcohol/wk). Abstinence group (no alcohol for 6 mo) (n=70) Control VS group (n=70) PRIMARY OUTCOME M 53 Atrial fibrillation recurrence % HR, 0.55; 95% CI, 0.36-0.84; P=0.005 73 0.5 Atrial fibrillation burden over 6mo (median % of time in AF) P=0.01 SECONDARY OUTCOME 1.2 Atrial fibrillation-related 9 hospital admissions % 20 Conclusion: Among regular drinkers, a substantial reduction in alcohol consumption by patients with symptomatic AF was associated with a reduction in recurrence of AF and a reduced proportion of time spent in AF. Aleksandr Voskoboinik et al. NEJM, 2020; 382:20-28