ELAN Trial Summary Introduction:The ELAN trial aimed to investigate the optimal timing of initiating direct oral anticoagulants (DOACs) in individuals with atrial fibrillation (AF) who had experienced an acute ischemic stroke. The study compared early anticoagulation (initiated within 48 hours or on day 6-7 after stroke) with later anticoagulation (initiated on day 3-4, day 6-7, […]
Tag: afib
Navigating the New Era: Landmark Clinical Trials on Eliquis (Apixaban) for Anticoagulation in Atrial Fibrillation
Atrial fibrillation (AFib) is a prevalent cardiac arrhythmia that significantly elevates the risk of stroke and systemic embolism. As a result, effective anticoagulation therapy is crucial for managing AFib patients. Over the past decade, novel oral anticoagulants (NOACs) have challenged traditional vitamin K antagonists, like warfarin, as preferred therapeutic options. Eliquis (apixaban) is one such […]
Pioneering the Path: Key Landmark Trials on Ablation Procedures for Atrial Fibrillation
Delve into the pivotal clinical trials that have shaped our understanding and management of atrial fibrillation through ablation procedures.
APAF Trial: Ablation or Antiarrhythmics for PAF
2006 APAF STUDY A randomized trial of circumferential pulmonary vein ablation versus antiarrhythmic drug therapy in paroxysmal atrial fibrillation (AF) randomized controlled trial M Objective: To compare the relative efficacy of circumferential pulmonary vein ablation (CPVA) & antiarrhythmic drug therapy (ADT) in the treatment of patients with paroxysmal atrial fibrillation (PAF) who have already […]
ACUTE Trial Summary: TEE-Guided Cardioversion for AFib
2001 ACUTE TRIAL Use of transesophageal echocardiography to guide cardioversion in patients with atrial fibrillation multicenter, prospective, randomized controlled trial Objective: To compare conventional anticoagulation strategy with the transesophageal echocardiography to guide short-term anticoagulant therapy in patients with atrial fibrillation prescribed with electrical cardioversion 1222 patients Inclusion criteria: Patients aged ≥18 years who had atrial […]
Surgical Ablation of AFib with MV Surgery
2015 SURGICAL ABLATION OF ATRIAL FIBRILLATION TRIAL Surgical ablation of atrial fibrillation during mitral-valve surgery parallel, randomized controlled trial M Objective: To evaluate treatment with mitral valve surgery plus ablation compared with mitral valve surgery alone among patients with mitral valve disease & persistent AF undergoing open heart surgery. 260 patients Inclusion criteria: Patients with […]
ALCOHOL-AF Trial Summary: Alcohol and AFib
2019 ALCOHOL-AF TRIAL Impact of Alcohol Abstinence in Moderate Drinkers With Atrial Fibrillation Randomized clinical trial Objective: To evaluate abstinence from alcohol compared with usual consumption among patients with atrial fibrillation and moderate alcohol consumption. 140 bel 53 5.6 9 Patients with Paroxysmal or persistent atrial fibrillation and an average alcohol intake ≥10 drinks per […]
Alcohol Abstinence in AFib Clinical Trial Summary
2020 ALCOHOL ABSTINENCE IN ATRIAL FIBRILLATION multicenter, prospective, open-label, randomized, controlled trial Objective: To assess the effect of abstinence from alcohol on secondary prevention of atrial fibrillation 140 patients Inclusion criteria: age of 18 to 85 years, presence of symptomatic paroxysmal AF (≥2 episodes in the 6 months) or symptomatic persistent AF with a rhythm-control […]
AFIRE Trial Summary: Antithrombotics in AFib and CAD
2019 AFIRE TRIAL Antithrombotic Therapy for Atrial Fibrillation with Stable Coronary Disease Multicenter, open-label trial conducted in Japan Objective: To evaluate the use of antithrombotic therapy in patients with atrial fibrillation and stable coronary artery disease. 2236 patients 4.14 Inclusion criteria: patients with atrial fibrillation who had undergone PCI or CABG more than 1 year […]
AFFIRM Trial Summary: Rate vs Rhythm Control for AFib
AFFIRM Trial: A Comparison of Rate Control and Rhythm Control in Patients with Atrial Fibrillation Multicenter, parallel-group, randomized, controlled trial Objective: Among patients with atrial fibrillation and a high risk of stroke or death, what are the effects of rate control versus rhythm control on mortality? Patients with atrial fibrillation Rate-control 4,060 Rhythm-control patients with […]