VITAL-AF Trial Summary The VITAL-AF trial aimed to determine whether point-of-care screening with a handheld single-lead ECG device during primary care visits increases the diagnosis of atrial fibrillation (AF) in older adults. The study randomized 16 primary care clinics in a 1:1 ratio, with half implementing AF screening using the AliveCor KardiaMobile device during vital […]
Tag: atrial fibrillation
Navigating the New Era: Landmark Clinical Trials on Eliquis (Apixaban) for Anticoagulation in Atrial Fibrillation
Atrial fibrillation (AFib) is a prevalent cardiac arrhythmia that significantly elevates the risk of stroke and systemic embolism. As a result, effective anticoagulation therapy is crucial for managing AFib patients. Over the past decade, novel oral anticoagulants (NOACs) have challenged traditional vitamin K antagonists, like warfarin, as preferred therapeutic options. Eliquis (apixaban) is one such […]
Pioneering the Path: Key Landmark Trials on Ablation Procedures for Atrial Fibrillation
Delve into the pivotal clinical trials that have shaped our understanding and management of atrial fibrillation through ablation procedures.
APAF Trial: Ablation or Antiarrhythmics for PAF
2006 APAF STUDY A randomized trial of circumferential pulmonary vein ablation versus antiarrhythmic drug therapy in paroxysmal atrial fibrillation (AF) randomized controlled trial M Objective: To compare the relative efficacy of circumferential pulmonary vein ablation (CPVA) & antiarrhythmic drug therapy (ADT) in the treatment of patients with paroxysmal atrial fibrillation (PAF) who have already […]
ACUTE Trial Summary: TEE-Guided Cardioversion for AFib
2001 ACUTE TRIAL Use of transesophageal echocardiography to guide cardioversion in patients with atrial fibrillation multicenter, prospective, randomized controlled trial Objective: To compare conventional anticoagulation strategy with the transesophageal echocardiography to guide short-term anticoagulant therapy in patients with atrial fibrillation prescribed with electrical cardioversion 1222 patients Inclusion criteria: Patients aged ≥18 years who had atrial […]
Surgical Ablation of AFib with MV Surgery
2015 SURGICAL ABLATION OF ATRIAL FIBRILLATION TRIAL Surgical ablation of atrial fibrillation during mitral-valve surgery parallel, randomized controlled trial M Objective: To evaluate treatment with mitral valve surgery plus ablation compared with mitral valve surgery alone among patients with mitral valve disease & persistent AF undergoing open heart surgery. 260 patients Inclusion criteria: Patients with […]
ALCOHOL-AF Trial Summary: Alcohol and AFib
2019 ALCOHOL-AF TRIAL Impact of Alcohol Abstinence in Moderate Drinkers With Atrial Fibrillation Randomized clinical trial Objective: To evaluate abstinence from alcohol compared with usual consumption among patients with atrial fibrillation and moderate alcohol consumption. 140 bel 53 5.6 9 Patients with Paroxysmal or persistent atrial fibrillation and an average alcohol intake ≥10 drinks per […]
Alcohol Abstinence in AFib Clinical Trial Summary
2020 ALCOHOL ABSTINENCE IN ATRIAL FIBRILLATION multicenter, prospective, open-label, randomized, controlled trial Objective: To assess the effect of abstinence from alcohol on secondary prevention of atrial fibrillation 140 patients Inclusion criteria: age of 18 to 85 years, presence of symptomatic paroxysmal AF (≥2 episodes in the 6 months) or symptomatic persistent AF with a rhythm-control […]
AFIRE Trial Summary: Antithrombotics in AFib and CAD
2019 AFIRE TRIAL Antithrombotic Therapy for Atrial Fibrillation with Stable Coronary Disease Multicenter, open-label trial conducted in Japan Objective: To evaluate the use of antithrombotic therapy in patients with atrial fibrillation and stable coronary artery disease. 2236 patients 4.14 Inclusion criteria: patients with atrial fibrillation who had undergone PCI or CABG more than 1 year […]
AFFIRM Trial Summary: Rate vs Rhythm Control for AFib
AFFIRM Trial: A Comparison of Rate Control and Rhythm Control in Patients with Atrial Fibrillation Multicenter, parallel-group, randomized, controlled trial Objective: Among patients with atrial fibrillation and a high risk of stroke or death, what are the effects of rate control versus rhythm control on mortality? Patients with atrial fibrillation Rate-control 4,060 Rhythm-control patients with […]