REVIVE Trial Summary: Exercise Program in Critically Ill after Discharge

revive trial exercise critically ill

2017 REVIVE TRIAL Effectiveness of an exercise programme on physical function in patients discharged from hospital following critical illness. | Multicentre, prospective phase II, randomised controlled trial Objective: To investigate the effectiveness of a 6 week exercise programme in patients discharged home following critical illness compared with standard care 60 patients Inclusion criteria: Critically ill patients aged >18 years and mechanically ventilated for > 96 hours Exercise programme (n=30) Standard care (n=30) PRIMARY OUTCOME 6.8 SF-36: Physical functioning at 6-weeksHR 1.31; 95% CI, 0.95 to 1.80; P=0.09 Diff 3.0; 95% CI-2.2 to 8.2; P=0.26 SECONDARY OUTCOMES 12.0 SF-36: Role physical Diff 6.6; 95% CI 0.73 to 12.5; P=0.03 5.4 135.5 Incremental shuttle walk test (in metres) Diff 83.1; 95% CI 8.3 to 157.9; P=0.03 52.4 -7.8 Functional limitations profile: overall score Diff -4.8; 95% CI -8.7 to -0.9; P=0.02 -3.0 Conclusion: After discharge from hospital following critical illness, a 6 week individualised exercise programme did not improve self-reported physical fitness at 6 weeks or 6 months, although encouraging results in secondary outcomes should be used for further studies on this theory K McDowell et al. Thorax 2017;72:600-609