WATERFALL Trial Summary The WATERFALL trial aimed to evaluate the effectiveness and safety of early aggressive hydration in the management of acute pancreatitis. While early aggressive hydration is a commonly recommended approach, limited evidence exists to support this practice. Conducted at 18 centers, the trial randomly assigned patients presenting with acute pancreatitis to receive either […]
Tag: fluids
WATERFALL Trial Summary: Fluids in Pancreatitis
2022 WATERFALL TRIAL Aggressive or moderate fluid resuscitation in acute pancreatitis multicenter, open-label, parallel-group, superiority, randomized controlled trial Objective: To evaluate the safety & efficacy of aggressive fluid resuscitation as compared with moderate fluid resuscitation for the management of acute pancreatitis 249 patients Patients ≥18 yrs with acute pancreatitis (Revised Atlanta Classification-meeting 2 of the […]
AMACING Trial Summary: IV Hydration for CIN
2017 AMACING TRIAL Prophylactic hydration to protect renal function from intravascular iodinated contrast material in patients at high risk of contrast-induced nephropathy. M Single-center, randomised, parallel-group, open-label, phase 3, non-inferiority trial 660 patients Objective: To evaluate the impact of prophylactic hydration with normal saline on rate of contrast-induced nephropathy in high-risk patients receiving contrast medium […]