2018 POLAR TRIAL Prophylactic hypothermia for severe traumatic brain injury Multicentre, partially-blinded, randomised controlled trial Objective: To determine the effectiveness of early prophylactic hypothermia compared with normothermic management of patients after severe traumatic brain injury 511 patients Inclusion criteria: Intubated blunt trauma patients (or imminent intubation) between age 18-60 yrs with clinical diagnosis of severe […]
Tag: TBI
COBI Trial Summary: Hypertonic Saline in Traumatic Brain Injury
2021 COBI TRIAL M Effect of continuous infusion of hypertonic saline vs standard care on 6-month neurological outcomes in patients with traumatic brain injury multicenter, parallel-group, open-label, randomized clinical trial Objective: To assess whether continuous infusion of 20% hypertonic saline solution improves neurological outcome at 6 months in patients with moderate to severe TBI. 5 […]