2021
VICTAS TRIAL
IM
Effect of vitamin C, thiamine, and hydrocortisone on ventilator-and vasopressor-free days in patients with sepsis
multicenter, double-blind, randomized controlled trial
Objective: To determine whether combination of vitamin C, thiamine & hydrocortisone every 6 hours increases ventilator- and vasopressor-free days compared with placebo in patients with sepsis.
501
Patients
Inclusion criteria: Patients aged ≥ 18 years with acute respiratory and/or cardiovascular dysfunction attributed to sepsis with planned ICU admission
Intervention (Vit C, thiamine & hydrocortisone) group [n=252]
25
25
VS
Control group [n=249]
PRIMARY OUTCOME
Ventilator & vasopressor free days Diff -1; 95% CI, -4 to 2; P=0.85
26
SECONDARY OUTCOMES
20.6
Mortality before ICU discharge % Diff 0.9; 95% CI, -8.0 to 6.1; P=0.79
19.7
40.5
Mortality at 180 days %
37.8
Diff 2.7; 95% CI, -11.3 to 5.8; P=0.53
10
10
Length of hospital stay (in days) Diff 1.0; 95% CI, -3.0 to 2.0; P=0.66
9
Conclusion: Among critically ill patients with sepsis, treatment with vitamin C, thiamine, and hydrocortisone, compared with placebo, did not significantly increase ventilator- and vasopressor-free days within 30 days.
JE Sevransky et al. JAMA 2021; 325(8):742-750
