VITAMINS Trial Summary The VITAMINS trial aimed to determine whether the combination of vitamin C, hydrocortisone, and thiamine is more effective than hydrocortisone alone in expediting the resolution of septic shock. The trial included 216 patients with septic shock and compared the duration of time alive and free of vasopressor administration over 7 days between […]
Tag: thiamine
VICTAS Trial: Vitamin C, Thiamine, and Hydrocortisone in Sepsis
2021 VICTAS TRIAL IM Effect of vitamin C, thiamine, and hydrocortisone on ventilator-and vasopressor-free days in patients with sepsis multicenter, double-blind, randomized controlled trial Objective: To determine whether combination of vitamin C, thiamine & hydrocortisone every 6 hours increases ventilator- and vasopressor-free days compared with placebo in patients with sepsis. 501 Patients Inclusion criteria: Patients […]
ACTS Trial: Ascorbic acid, Steroids and Thiamine in Septic Shock
2020 ACTS TRIAL Effect of ascorbic acid, corticosteroids, and thiamine on organ injury in septic shock Multicenter, randomized, blinded, placebo-controlled superiority trial M Objective: To determine whether the combination of ascorbic acid, corticosteroids, and thiamine attenuates organ injury in patients with septic shock. 205 patients Inclusion criteria: Patients ≥18 years of age with infection and […]
ATESS Trial Summary: Vitamin C + Thiamine for Septic Shock
2020 ATESS TRIAL Combination therapy of vitamin C and thiamine for septic shock Multicentre, double-blind, randomized controlled trial Objective: To evaluate the effects of early combination therapy with intravenous vitamin C and thiamine on recovery from organ failure in patients with septic shock. 111 Adult patients who presented to ED and diagnosed with septic shock […]
VITAMINS Trial: Vitamin C, hydrocortisone, and thiamine in Septic Shock
2021 2021 VITAMINS TRIAL M Effect of Vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock Open label, multi-centre, randomized, phase IIb clinical trial Objective: To investigate whether treatment with Vitamin C, hydrocortisone & thiamine (intervention) lead to a more rapid resolution of […]