NOTUS TRIAL Dupilumab for COPD with Blood Eosinophil Evidence of Type 2 Inflammation A double-blind, placebo-controlled, randomized trial Objective:To assess the efficacy and safety of dupilumab in patients with moderate to severe COPD and evidence of type 2 inflammation. 935 … Read More
Pulmonology
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NADIM II Trial: Nivolumab in Lung Cancer
Objective: To examine the pathological Complete Response defined as the absence of residual tumor in lung and lymph nodes comparing patients treated with chemo-immunotherapy versus chemotherapy alone. Inclusion Criteria: Exclusion Criteria: Participants: 86 Patients Treatment Groups: Primary Outcome: Secondary Outcomes: … Read More
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ACTIV-6 Trial: Inhaled Fluticasone in Covid-19
The ACTIV-6 trial, published in the New England Journal of Medicine in 2023, examines the effectiveness of inhaled fluticasone furoate in the treatment of non-hospitalized patients with mild to moderate COVID-19. The trial was a decentralized, double-blind, randomized, placebo-controlled study … Read More
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ANTHARTIC Trial: Preventing VAP after CA
2019 ANTHARTIC TRIAL M Prevention of early Ventilator-Associated Pneumonia after cardiac arrest Multicentre, randomised, double-blind, placebo-controlled Objective: To investigate whether in post out-of-hospital cardiac arrest (OOHCA) patients treated with targeted temperature management, does the use of empirical antibiotics prevent early … Read More
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ANT 005 TKA Trial: Abelacimab for VTE
2021 ANT-005 TKA TRIAL M Abelacimab for Prevention of Venous Thromboembolism (VTE) Phase 2,open-label, prospective randomized trial 400 Objective: To compare the efficacy & safety of abelacimab administered postoperatively with the efficacy & safety of enoxaparin in patients undergoing … Read More
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AMPLIFY Trial: Apixaban for acute VTE
2013 AMPLIFY TRIAL Oral Apixaban for the Treatment of Acute Venous Thromboembolism double-blind, multicenter, randomized controlled trial IM Objective: To determine if apixaban is non-inferior to conventional therapy with LMWH in patients with pulmonary embolism or proximal deep venous thrombosis … Read More
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CANARY Trial Summary: Cath vs AC in PE
2022 CANARY TRIAL Catheter-directed thrombolysis vs anticoagulation in patients with acute intermediate-high-risk pulmonary embolism parallel, open-label, randomized controlled trial Objective: To assess the effectiveness of catheter-directed thrombolysis (CCDT) compared with anticoagulation among intermediate- to high-risk individuals with acute pulmonary embolism … Read More
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SERVE HF Trial Summary: Adaptive sero-ventilation for CSA in HF
2015 SERVE-HF TRIAL M Adaptive servo-ventilation for central sleep apnea in systolic heart failure parallel, randomized controlled trial Objective: To assess the effectiveness of adaptive servo-ventilation Damong subjects with heart failure with reduced ejection fraction and central sleep apnea 1315 … Read More
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AMAZES Trial Summary: Azithromycin in Asthma
2017 AMAZES TRIAL Azithromycin in asthma exacerbations Multicenter, double-blind, placebo controlled parallel group trial M Objective: In adult patients with symptomatic asthma who are currently using an inhaled corticosteroid or a long-acting bronchodilator, does oral azithromycin decrease the frequency of … Read More
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ACURASYS Trial Summary: NM blockers in ARDS
2010 ACURASYS TRIAL Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome Multicenter, double-blinded, placebo-controlled trial Objective: To assess if administration of cisatracurium improve survival when compared to placebo in ICU patients undergoing mechanical ventilation for early severe ARDS 340 patients … Read More