Pulmonology

ACTIV-6 Trial: Inhaled Fluticasone in Covid-19

The ACTIV-6 trial, published in the New England Journal of Medicine in 2023, examines the effectiveness of inhaled fluticasone furoate in the treatment of non-hospitalized patients with mild to moderate COVID-19. The trial was a decentralized, double-blind, randomized, placebo-controlled study … Read More

ANTHARTIC Trial: Preventing VAP after CA

2019 ANTHARTIC TRIAL M Prevention of early Ventilator-Associated Pneumonia after cardiac arrest Multicentre, randomised, double-blind, placebo-controlled Objective: To investigate whether in post out-of-hospital cardiac arrest (OOHCA) patients treated with targeted temperature management, does the use of empirical antibiotics prevent early … Read More

ANT 005 TKA Trial: Abelacimab for VTE

 2021 ANT-005 TKA TRIAL M Abelacimab for Prevention of Venous Thromboembolism (VTE) Phase 2,open-label, prospective randomized trial 400 Objective: To compare the efficacy & safety of abelacimab administered postoperatively with the efficacy & safety of enoxaparin in patients undergoing … Read More

AMPLIFY Trial: Apixaban for acute VTE

2013 AMPLIFY TRIAL Oral Apixaban for the Treatment of Acute Venous Thromboembolism double-blind, multicenter, randomized controlled trial IM Objective: To determine if apixaban is non-inferior to conventional therapy with LMWH in patients with pulmonary embolism or proximal deep venous thrombosis … Read More

CANARY Trial Summary: Cath vs AC in PE

2022 CANARY TRIAL Catheter-directed thrombolysis vs anticoagulation in patients with acute intermediate-high-risk pulmonary embolism parallel, open-label, randomized controlled trial Objective: To assess the effectiveness of catheter-directed thrombolysis (CCDT) compared with anticoagulation among intermediate- to high-risk individuals with acute pulmonary embolism … Read More

SERVE HF Trial Summary: Adaptive sero-ventilation for CSA in HF

2015 SERVE-HF TRIAL M Adaptive servo-ventilation for central sleep apnea in systolic heart failure parallel, randomized controlled trial Objective: To assess the effectiveness of adaptive servo-ventilation Damong subjects with heart failure with reduced ejection fraction and central sleep apnea 1315 … Read More

AMAZES Trial Summary: Azithromycin in Asthma

2017 AMAZES TRIAL Azithromycin in asthma exacerbations Multicenter, double-blind, placebo controlled parallel group trial M Objective: In adult patients with symptomatic asthma who are currently using an inhaled corticosteroid or a long-acting bronchodilator, does oral azithromycin decrease the frequency of … Read More

ACURASYS Trial Summary: NM blockers in ARDS

2010 ACURASYS TRIAL Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome Multicenter, double-blinded, placebo-controlled trial Objective: To assess if administration of cisatracurium improve survival when compared to placebo in ICU patients undergoing mechanical ventilation for early severe ARDS 340 patients … Read More

PADN-CFDA Trial Summary: PA Denervation for PAH

2022 PADN-CFDA TRIAL Pulmonary artery denervation for pulmonary arterial hypertension (PAH) multicenter, sham-controlled single-blind, randomized controlled trial Objective: To evaluate the treatment effects of pulmonary artery denervation (PADN) among patients with Group I PAH who were not on PAH-specific drugs … Read More

REDECAP Trial Summary: High-Flow Oxygen for Tracheostomy Decannulation

2020 REDECAP TRIAL M High-flow oxygen with capping or suctioning for tracheostomy decannulation Multicentre randomised controlled trial So Objective: To compare an assessment of readiness for decannulation that is based on suctioning frequency with an assessment based on tracheostomy capping … Read More