Hypertension remains a major global health issue, particularly for patients whose blood pressure remains uncontrolled despite multiple medications. The Advance-HTN trial, presented at ACC.25 in Chicago in 2025, provides compelling evidence for the use of lorundrostat, a novel aldosterone synthase … Read More
General Medicine
TIME Trial: Evening versus morning dosing of usual antihypertensives
TIME StudyHypertension Treatment in Morning versus Evening Objective:To determine whether evening dosing of antihypertensive medication improves major cardiovascular outcomes compared to morning dosing in patients with hypertension. Study Design: Participants: Primary Endpoint: Results: Conclusion:Evening dosing of antihypertensive medication did not … Read More
AMBER Trial: Patiromer to Allow Spironolactone use in Resistant Hypertension
Resistant hypertension poses a significant challenge, especially in patients with chronic kidney disease (CKD). The AMBER trial emerges as a beacon of hope, evaluating the role of the potassium binder patiromer in enabling the use of spironolactone in this difficult-to-treat … Read More
GZGI Trial: Orforglipron in Obesity
GZGI TRIAL Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity Phase 2, randomized, double-blind, placebo-controlled trial Objective:To assess the efficacy and safety of orforglipron, an oral non-peptide GLP-1 receptor agonist, for weight reduction in adults with obesity, or … Read More
Bridge-TIMI 73a Trial: Olezarsen for Hypertriglyceridemia
Bridge–TIMI 73a Trial Olezarsen for Hypertriglyceridemia in Patients at High Cardiovascular Risk A randomized, placebo-controlled, double-blind trial Objective:To assess the efficacy and safety of olezarsen for lowering triglyceride levels in patients with moderate hypertriglyceridemia plus elevated cardiovascular risk and in … Read More
FCS BALANCE: Olezarsen in Familial Chylomicronemia Syndrome
FCS BALANCE Trial Olezarsen, Acute Pancreatitis, and Familial Chylomicronemia Syndrome (FCS) A phase 3, double-blind, placebo-controlled trial Objective:To assess the efficacy and safety of olezarsen (given once every 4 weeks) in reducing fasting triglyceride level in patients with familial chylomicronemia … Read More
E-Cigarettes in Smoking Cessation: A New Tool in the Fight Against Tobacco
Introduction E-cigarettes, also known as electronic cigarettes or vapes, have emerged as a controversial but increasingly popular tool for smoking cessation. As healthcare providers, it’s crucial to understand the potential benefits and risks associated with e-cigarette use, especially in the … Read More
Target-HTN trial: Lorundrostat in Hypertension
The TARGET-HTN trial, published in JAMA in September 2023, investigated the safety and efficacy of lorundrostat, an aldosterone synthase inhibitor, in treating patients with uncontrolled hypertension. This randomized, placebo-controlled, dose-ranging trial included 200 patients who were adults with uncontrolled hypertension … Read More
RADIANCE-HTN TRIO Trial: Renal Denervation in HTN
The RADIANCE-HTN TRIO trial, detailed in The Lancet in 2021, is another pivotal study in the domain of hypertension treatment, focusing on a challenging group of patients: those resistant to a standard triple combination pill. This trial delves into the … Read More
RADIANCE-HTN SOLO Trial: Renal Denervation in HTN
The RADIANCE-HTN SOLO trial, published in The Lancet in May 2018, marks a significant stride in hypertension treatment research. This trial focused on the safety and efficacy of a novel endovascular ultrasound renal denervation procedure compared to a sham procedure … Read More