2011 AIM-HIGH TRIAL Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy Placebo controlled, randomized clinical trial Σ Objective: To assess if extended-release niacin added to simvastatin to raise low levels of high-density lipoprotein (HDL) cholesterol is … Read More
General Medicine
AGE Trial Summary: Mammogram Screening for Breast Cancer
AGE: Effect of mammographic screening from age 40 years on breast cancer mortality Multicenter, open label randomized comparative trial Objective: To assess if initiation of breast cancer screening with mammograms at age 40-41 reduces breast cancer mortality Women age 39-41 … Read More
NORDICC Trial Summary: Colonoscopy for Colorectal Cancer Screening
2022 NORDICC TRIAL Effect of colonoscopy screening on risks of colorectal cancer and related death pragmatic, multicenter, randomized controlled trial Objective: To investigate the effects of population-based colonoscopy screening on the risks of colorectal cancer and related death at 10 … Read More
ACCOMPLISH Trial: Benazepril + Amlodipine or HCTZ for Hypertension
2008 ACCOMPLISH TRIAL Benazepril plus Amlodipine or Hydrochlorothiazide for Hypertension in High-Risk Patients Multi-centered, double-blind, randomized, controlled trial Objective: To evaluate the effect of amlodipine vs. hydrochlorothiazide in patients with hypertension and at high risk for cardiovascular disease. E 11,506 … Read More
ACCORD BP Trial Summary: Intensive BP Control in Type 2 Diabetes
2010 ACCORD BP TRIAL Effects of intensive blood-pressure control in type 2 diabetes mellitus Multicenter, randomized, controlled, open-label trial Objective: In patients with T2DM at high risk for CV events, does intensive BP control (SBP <120 mmHg) reduce rates of … Read More
SODIUM-HF Trial Summary: Reduction of dietary sodium in Heart Failure
2022 SODIUM-HF TRIAL Reduction of dietary sodium to less than 100 mmol in heart failure International, open-label, randomised, controlled trial Objective: To evaluate if a low-sodium diet (<1500 mg daily) compared to usual care in ambulatory patients with heart failure … Read More
PRECISE Trial Summary: Pregabalin for Acute and Chronic Sciatica
2017 PRECISE TRIAL Trial of pregabalin for acute and chronic sciatica Randomized, double-blind, placebo-controlled trial Objective: To determine whether pregabalin reduces the intensity of sciatica as compared to placebo 209 Inclusion criteria: Sciatica patients aged > 18 years having: – … Read More
VITAL Trial: Vitamin D and Incident Fractures
2022 VITAL TRIAL Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults double-blind, placebo-controlled, 2×2 factorial, randomized controlled trial Objective: To investigate the effects of supplemental vitamin D3 as compared with placebo on incident fractures among generally healthy … Read More