VITAL-DEP Trial Summary The VITAL-DEP trial aimed to investigate whether long-term supplementation with vitamin D3 could prevent depression in the general adult population. The study included 18,353 adults aged 50 years or older without depression or clinically relevant depressive symptoms at the beginning of the trial. The participants were randomly assigned to receive either vitamin […]
Category: Psychiatry
ELEKT-D Trial: Ketamine vs. ECT for Treatment-Resistant Major Depression
ELEKT-D Trial: Ketamine vs. ECT for Treatment-Resistant Major Depression Introduction:The groundbreaking ELEKT-D Trial sought to compare the efficacy of electroconvulsive therapy (ECT) and subanesthetic intravenous ketamine for the treatment of patients with treatment-resistant major depression. This study aimed to determine whether ketamine was noninferior to ECT in producing a treatment response and explored secondary outcomes […]
ANTLER Trial: Antidepressants in Primary care
2021 ANTLER TRIAL Maintenance or discontinuation of antidepressants in primary care Multicenter, randomized, double-blind trial M Objective: To assess the effects of maintenance antidepressant therapy, as compared with discontinuation of treatment, in patients taking antidepressants 478 patients Inclusion criteria: Participants 18 to 74 years of age with >2 prior episodes of depression or took […]
PRIME Care Trial Summary: Pharmacogenomic Testing for Drug-Gene Interactions in Depression Treatment
2022 PRIME CARE TRIAL Effect of Pharmacogenomic Testing for Drug-Gene Interactions on Medication Selection in Major Depressive Disorder Randomised, pragmatic, clinical trial Objective: To assess if pharmacogenomic testing for drug-gene interactions affects the selection of antidepressant medication and response in patients with major depressive disorder (MDD)? 4 Patients with MDD who were initiating or switching […]