Explore the transformative clinical trials that have solidified the role of SGLT2 inhibitors in heart failure management and their potential to redefine the treatment landscape. Introduction Heart failure is a complex clinical syndrome associated with significant morbidity and mortality. In recent years, sodium-glucose cotransporter-2 (SGLT2) inhibitors have emerged as a promising new class of drugs […]
Tag: heart failure
The Data Behind HFpEF Management: Landmark Clinical Trials on Heart Failure with Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) is a complex and increasingly prevalent form of heart failure, accounting for nearly half of all heart failure cases. Despite its significance, HFpEF remains a challenging condition to manage and treat, as effective therapies have been limited. In this article, we delve into the landmark clinical trials that […]
MADIT-CRT Trial Summary: CRT in HF
2009 MADIT-CRT TRIAL Cardiac-Resynchronization Therapy for the prevention of heart-failure events multicenter, open-label, randomized controlled trial Objective: To determine whether cardiac-resynchronization therapy with implantable cardioverter-defibrillator (CRT-ICD) would reduce the risk of death or heart-failure events in M patients with mild cardiac symptoms, reduced ejection fraction, and wide QRS complex. 1820 patients Inclusion criteria: Patients aged […]
COACH Trial Summary: Access to Care in Heart Failure
2022 COACH TRIAL Trial of an intervention to improve acute heart failure outcomes cross-sectional, cluster-randomized trial M Objective: To determine the effectiveness of systematic use of a hospital-based point-of-care tool to support clinical decision-making, followed by rapid follow-up in an outpatient clinic among patients with acute heart failure seeking emergency care 5452 patients Inclusion criteria: […]
AF-CHF Trial Summary: Rhythm vs Rate Control for AFib and HF
AF-CHF: Rhythm Control versus Rate Control for Atrial Fibrillation and Heart Failure Multicenter, prospective, randomized, controlled trial Objective: To assess if rhythm-control reduce CV mortality in patients with AF and HFrEF as compared to rate control. Patients with AF and HFREF rate control rhythm control CV mortality 1,376 patients with nonvalvular atrial fibrillation and HFREF […]
PERSPECTIVE Trial Summary: Sacubitril/valsartan Effect on Cognition in HFpEF
2022 PERSPECTIVE TRIAL M Efficacy and safety of sacubitril/valsartan compared to valsartan on cognitive function in patients with chronic heart failure and preserved ejection fraction parallel, randomized controlled trial Objective: To evaluate the effectiveness of sacubitril/valsartan compared with valsartan alone among symptomatic heart failure patients 592 Patients Inclusion criteria: Patients ≥60 years with (1) chronic […]
A-HEFT Trial Summary: Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure
2004 -0.1 3.1 A-HEFT TRIAL Combination of Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure Inclusion criteria: patients self-identified as 1,050 black (of African descent) with NYHA class III-IV patients HF ≥3 months on standard therapy, including ACEI/ARBs, ẞ-blockers, spironolactone, diuretics 6.2 double-blinded, parallel-group, randomized, placebo-controlled Objective: Among self-identified black patients with HFREF, does […]
AATAC Trial Summary: Ablation vs. amiodarone for Persistent Atrial Fibrillation
2016 AATAC TRIAL Ablation vs. amiodarone for treatment of persistent atrial fibrillation in CHF Multicenter, parallel-group, open-label, randomized Objective: To assess if AF ablation is superior to y amiodarone in patients with symptomatic (NYHA II-III) heart failure with reduced ejection fraction (LVEFS 40%) and persistent atrial fibrillation (AF) 203 patients (age 18 years) with persistent […]
TAVR with Self-Expanding Prosthesis Trial Summary
2014 COREVALVE HIGH-RISK TRIAL Transcatheter aortic-valve replacement (TAVR) with a self-expanding prosthesis Multicenter, randomized, non inferiority trial “‘Objective: To compare TAVR using a self-expanding a transcatheter aortic-valve bioprosthesis, with surgical aortic-valve replacement in patients with severe aortic stenosis & an increased risk of death during surgery 795 Inclusion criteria: Patients with severe aortic stenosis & […]
ADVOR Trial Summary: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload
2022 ADVOR STUDY Acetazolamide in acute decompensated heart failure with volume overload multicenter, parallel-group, double-blind, randomized, placebo-controlled trial a d Objective: To compare the incidence of successful decongestion with addition of acetazolamide vs placebo to loop diuretic therapy in patients with acute decompensated heart failure 519 Adults 18 years with clinical signs of volume overload […]