coronary artery disease

GLAGOV Trial: Evolocumab on CAD Progression

GLAGOV Trial: Effect of Evolocumab on Coronary Disease Progression in Statin-Treated Patients The GLAGOV trial is a double-blind, placebo-controlled, randomized study designed to assess the impact of PCSK9 inhibition with evolocumab on the progression of coronary atherosclerosis in patients already … Read More

EPIC-CAD Trial: Edoxaban in CAD and AF

The EPIC-CAD trial, recently published in The New England Journal of Medicine, evaluated the efficacy and safety of edoxaban monotherapy compared to dual antithrombotic therapy in patients with stable coronary artery disease (CAD) and high-risk atrial fibrillation (AF). This open-label, … Read More

EMPACT-MI: Empagliflozin after MI

Year: 2024 Title: EMPACT-MI Subtitle: Empagliflozin after Acute Myocardial Infarction Type of Trial: A double-blind, randomized, placebo-controlled trial Objective: To assess if the use of empagliflozin in the treatment of acute myocardial infarction (AMI) affects future mortality or heart failure … Read More

OCTOBER Trial: OCT in Complex PCI

The OCTOBER trial, detailed in the New England Journal of Medicine in 2023, was a multicenter, randomized, open-label trial designed to assess the effectiveness of optical coherence tomography (OCT) in guiding percutaneous coronary intervention (PCI) for the treatment of complex … Read More

ISCHEMIA Trial: Invasive or Medical therapy for Stable CAD

2020 ISCHEMIA TRIAL M Initial Invasive or Conservative Strategy for Stable Coronary Disease multicenter, parallel, randomized controlled trial Objective: Tto determine the effect of adding cardiac catheterization (hereafter, angiography) and revascularization when feasible to medical therapy in patients with stable … Read More

ADAPTABLE Trial Summary: Aspirin Dosing in CV Disease

2013 ADAPTABLE TRIAL Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease Open-label, pragmatic design, randomized controlled trial M Objective: To assess whether a strategy of aspirin 325 mg/day would result in a lower risk of death from any cause, hospitalization … Read More

ISCHEMIA-CKD Trial Summary: CAD Management in Advanced CKD

2020 ISCHEMIA-CKD TRIAL Management of coronary disease in patients with advanced kidney disease international, randomized controlled trial Objective: To compare the effectiveness of routine invasive therapy with optimal medical therapy among patients with stable coronary disease & advanced chronic kidney … Read More

POPULAR CABG Trial Summary: Ticagrelor in CABG

2020 POPULAR CABG TRIAL Effect of adding ticagrelor to standard aspirin on saphenous vein graft (SVG) patency in patients undergoing coronary artery bypass grafting double-blind, placebo-controlled, multicenter, randomized controlled trial M Objective: To assess whether ticagrelor added to standard aspirin … Read More