Tag: myocardial infarction

BRIGHT-4 Trial Summary: Bivalirudin in STEMI

2022 BRIGHT-4 TRIAL Bivalirudin plus a high-dose infusion versus heparin monotherapy in patients with STEMI undergoing primary PCI investigator-initiated, open-label, randomized controlled trial Objective: To evaluate the safety and efficacy of a high-dose infusion of bivalirudin after primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) compared with unfractionated heparin 6016 […]

TRANSFER AMI Trial Summary: Early Angioplasty after Fibrinolysis for Acute MI

2009 TRANSFER-AMI trial: Routine Early Angioplasty after Fibrinolysis for Acute Myocardial Infarction Multicenter, randomized, non-blinded, parallel Assignment Objective: To assess outcomes in patients with AMI treated with thrombolysis transferring to a center providing PCI for standard treatment (rescue PCI or delayed angiography) vs immediate transfer within 6 hours of fibrinolysis 1059 Patients > 18 years […]

PARADISE MI Trial Summary: Sacubitril-valsartan vs ramipril in acute MI

2021 PARADISE-MI M Angiotensin Receptor-Neprilysin Inhibition in Acute Myocardial Infarction international, multicenter, randomized, double-blind, active-comparator trial S S 1. Objective: To compare the effects of sacubitril-valsartan and angiotensin converting-enzyme inhibitor, ramipril in patients with acute myocardial infarction 5661 Inclusion criteria: Adults without history of heart failure but spontaneous myocardial infarction with a reduced left ventricular […]