PCI

OCTOBER Trial: OCT in Complex PCI

The OCTOBER trial, detailed in the New England Journal of Medicine in 2023, was a multicenter, randomized, open-label trial designed to assess the effectiveness of optical coherence tomography (OCT) in guiding percutaneous coronary intervention (PCI) for the treatment of complex … Read More

FIRE Trial: Complete PCI in MI in Older Patients

The FIRE trial, published in the New England Journal of Medicine in 2023, was a multicenter, randomized controlled trial that aimed to evaluate the benefits of complete revascularization versus culprit-lesion-only percutaneous coronary intervention (PCI) in older patients (≥75 years of … Read More

ORBITA-2 Trial: PCI in Stable Angina

Understanding the Impact of PCI in Stable Angina: Insights from the ORBITA-2 Trial The ORBITA-2 trial has emerged as a cornerstone study in the field of cardiology, particularly in the treatment of stable angina through Percutaneous Coronary Intervention (PCI). This … Read More

WOEST Trial Summary: Clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing PCI

WOEST Trial Summary The WOEST trial, a groundbreaking study published in The Lancet, has shed light on a significant issue faced by patients undergoing percutaneous coronary intervention (PCI) while taking oral anticoagulants. Traditionally, triple therapy involving aspirin and clopidogrel has … Read More

BRIGHT-4 Trial Summary: Bivalirudin in STEMI

2022 BRIGHT-4 TRIAL Bivalirudin plus a high-dose infusion versus heparin monotherapy in patients with STEMI undergoing primary PCI investigator-initiated, open-label, randomized controlled trial Objective: To evaluate the safety and efficacy of a high-dose infusion of bivalirudin after primary percutaneous coronary … Read More

SECURE PCI Trial Summary: Loading Atorvastatin in ACS

2018 SECURE-PCI TRIAL Effect of loading dose of atorvastatin prior to planned percutaneous coronary intervention on major adverse cardiovascular events in acute coronary syndrome double-blind, multicenter, randomized controlled trial Objective: To determine if periprocedural loading doses of atorvastatin decrease 30-day … Read More

AIDA Trial Summary: Bioabsorbable Scaffolds for Routine PCI

2017 AIDA TRIAL Bioresorbable scaffolds versus metallic stents in routine PCI Prospective, multi-center, single-blind, randomized controlled trial M Objective: To assess if bioresorbable scaffolds superior to standard drug-eluting stents (DES) with regard to target-vessel failure in patients with stable or … Read More

TRANSFER AMI Trial Summary: Early Angioplasty after Fibrinolysis for Acute MI

2009 TRANSFER-AMI trial: Routine Early Angioplasty after Fibrinolysis for Acute Myocardial Infarction Multicenter, randomized, non-blinded, parallel Assignment Objective: To assess outcomes in patients with AMI treated with thrombolysis transferring to a center providing PCI for standard treatment (rescue PCI or … Read More