Explore the pivotal clinical trials that have shaped our understanding of the role of steroids in the management of septic shock, unveiling the complexities and nuances of this controversial topic. Introduction Septic shock is a life-threatening condition characterized by a dysregulated host response to infection, leading to circulatory and metabolic abnormalities. The use of steroids […]
Tag: glucocorticoids
ADRENAL Trial Summary: Steroids in Septic Shock
ADJUNCTIVE GLUCOCORTICOID THERAPY IN PATIENTS WITH SEPTIC SHOCK – THE ADRENAL TRIAL Multicenter, double-blind, parallel-group, randomized, controlled trial 3,658 patients with septic shock requiring vasopressors and mechanical ventilation were randomized to VS Hydrocortisone Placebo (n=1,832) (n=1,826) Mean follow-up: 90 Days PRIMARY OUTCOMES 27.9% Death from Any Cause at 90 Days 28.8% 3 P=0.50 © SECONDARY […]