steroids

Navigating the Controversy: A Comprehensive Review of Landmark Clinical Trials on Steroids Use in Septic Shock

Explore the pivotal clinical trials that have shaped our understanding of the role of steroids in the management of septic shock, unveiling the complexities and nuances of this controversial topic. Introduction Septic shock is a life-threatening condition characterized by a … Read More

AIRTRIP Trial Summary: Anakinra in Recurrent Pericarditis

2016 AIRTRIP TRIAL Effect of anakinra on recurrent pericarditis among patients with colchicine resistance and dependance M Multicenter, double-blind, placebo-controlled, open-label, medication withdrawal study Objective: To determine the efficacy of anakinra for colchicine-resistant and corticosteroid-dependent recurrent pericarditis 21 Inclusion criteria: … Read More

ADRENAL Trial Summary: Steroids in Septic Shock

ADJUNCTIVE GLUCOCORTICOID THERAPY IN PATIENTS WITH SEPTIC SHOCK – THE ADRENAL TRIAL Multicenter, double-blind, parallel-group, randomized, controlled trial 3,658 patients with septic shock requiring vasopressors and mechanical ventilation were randomized to VS Hydrocortisone Placebo (n=1,832) (n=1,826) Mean follow-up: 90 Days … Read More

TESTING Trial Summary: Methylprednisolone in IgA Nephropathy

2022 TESTING TRIAL Effect of oral Methylprednisolone on clinical outcomes in patients with IgA nephropathy Multicenter, investigator-initiated, double-blind, randomized clinical trial Objective: To evaluate the efficacy and safety of corticosteroids in patients with IgA nephropathy at risk of progression as … Read More

VITAMINS Trial: Vitamin C, hydrocortisone, and thiamine in Septic Shock

2021 2021 VITAMINS TRIAL M Effect of Vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock Open label, multi-centre, randomized, phase IIb clinical trial Objective: To investigate whether … Read More

DREAMS Trial Summary: Dexamethasone for Post-op Nausea and Vomiting

2017 DREAMS TRIAL Dexamethasone vs standard treatment for postoperative nausea and vomiting (PONV) in gastrointestinal surgery Pragmatic, blinded, multicentre,randomised controlled trial Objective: To determine reduction in PONV by preoperative Dexamethasone in patients undergoing elective bowel surgery & its association with … Read More