Explore the pivotal clinical trials that have shaped our understanding of the role of steroids in the management of septic shock, unveiling the complexities and nuances of this controversial topic. Introduction Septic shock is a life-threatening condition characterized by a dysregulated host response to infection, leading to circulatory and metabolic abnormalities. The use of steroids […]
Tag: steroids
AIRTRIP Trial Summary: Anakinra in Recurrent Pericarditis
2016 AIRTRIP TRIAL Effect of anakinra on recurrent pericarditis among patients with colchicine resistance and corticosteroid dependance M Multicenter, double-blind, placebo-controlled, open-label, medication withdrawal study Objective: To determine the efficacy of anakinra for colchicine-resistant and corticosteroid-dependent recurrent pericarditis 21 Inclusion criteria: Patients of age 2-70 years who had recurrent idiopathic pericarditis (with > 3 previous […]
ADRENAL Trial Summary: Steroids in Septic Shock
ADJUNCTIVE GLUCOCORTICOID THERAPY IN PATIENTS WITH SEPTIC SHOCK – THE ADRENAL TRIAL Multicenter, double-blind, parallel-group, randomized, controlled trial 3,658 patients with septic shock requiring vasopressors and mechanical ventilation were randomized to VS Hydrocortisone Placebo (n=1,832) (n=1,826) Mean follow-up: 90 Days PRIMARY OUTCOMES 27.9% Death from Any Cause at 90 Days 28.8% 3 P=0.50 © SECONDARY […]
TESTING Trial Summary: Methylprednisolone in IgA Nephropathy
2022 TESTING TRIAL Effect of oral Methylprednisolone on clinical outcomes in patients with IgA nephropathy Multicenter, investigator-initiated, double-blind, randomized clinical trial Objective: To evaluate the efficacy and safety of corticosteroids in patients with IgA nephropathy at risk of progression as compared to placebo 262 (1) IgA nephropathy proven on renal biopsy (2) Proteinuria:2 1.0g/day (3) […]
VITAMINS Trial: Vitamin C, hydrocortisone, and thiamine in Septic Shock
2021 2021 VITAMINS TRIAL M Effect of Vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock Open label, multi-centre, randomized, phase IIb clinical trial Objective: To investigate whether treatment with Vitamin C, hydrocortisone & thiamine (intervention) lead to a more rapid resolution of […]
DREAMS Trial Summary: Dexamethasone for Post-op Nausea and Vomiting
2017 DREAMS TRIAL Dexamethasone vs standard treatment for postoperative nausea and vomiting (PONV) in gastrointestinal surgery Pragmatic, blinded, multicentre,randomised controlled trial Objective: To determine reduction in PONV by preoperative Dexamethasone in patients undergoing elective bowel surgery & its association with other measurable benefits during recovery from surgery. 1350 patients Inclusion criteria: Adults over 18 years […]