DUPLEX Trial: Sparsentan in FSGS

The DUPLEX Trial: Evaluating Kidney Protection in FSGS Patients The DUPLEX trial, a rigorous study published in the New England Journal of Medicine in 2023, has garnered significant attention in the nephrology community. The trial investigated the long-term nephroprotective potential … Read More

The Data Behind HFpEF Management: Landmark Clinical Trials on Heart Failure with Preserved Ejection Fraction

Heart failure with preserved ejection fraction (HFpEF) is a complex and increasingly prevalent form of heart failure, accounting for nearly half of all heart failure cases. Despite its significance, HFpEF remains a challenging condition to manage and treat, as effective … Read More

AIMS Trial Summary: Irbesartan in Marfan Syndrome

2019 AIMS TRIAL Irbesartan in Marfan syndrome Placebo-controlled, double-blind randomised trial Objective: To evaluate an angiotensin receptor blocker (ARB) compared with placebo among patients with confirmed Marfan syndrome. 192 patients Inclusion criteria: Patients with clinically confirmed Marfan syndrome, 6-40 years … Read More