WAKE-UP Trial Summary The WAKE-UP trial aimed to investigate the potential benefits of intravenous alteplase, a thrombolytic agent, in treating acute stroke patients with an unknown time of onset. Current guidelines recommend intravenous thrombolysis only if the time since symptom onset is less than 4.5 hours. However, the trial sought to determine whether patients with […]
Tag: stroke
BASICS Trial: Endovascular Therapy for Basilar Stroke
2021 BASICS TRIAL Endovascular therapy for stroke due to basilar-artery occlusion multicenter, open-label, randomized controlled trial M Objective: To determine effectiveness of endovascular therapy in patients with stroke caused by basilar-artery occlusion. 300 patients. Inclusion criteria: Patients aged ≥ 18 years with symptoms and signs compatible with ischemia in the basilar artery territory مجھے Endovascular […]
ACTIVE W Trial Summary: Clopidogrel + ASA vs. OAC for Atrial Fibrillation
2006 ACTIVE W TRIAL Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation Randomized, open treatment, controlled trial M Objective: Among patients with nonvalvular AF, how does combination aspirin/clopidogrel compare to warfarin in reducing the incidence of stroke, systemic embolism, MI, or CV death? Inclusion criteria: patients with AF and ≥1 additional 6,706 stroke risk […]
ACTIVE A Trial Summary: Clopidogrel + Aspirin in Atrial Fibrillation
2009 ACTIVE A TRIAL Effect of Clopidogrel Added to Aspirin in Patients with Atrial Fibrillation Multicenter, double-blind, parallel-group trial M Objective: To assess if the addition of clopidogrel to aspirin reduces the risk of vascular events compared to aspirin alone in patients with atrial fibrillation who are not suitable candidates for vitamin K antagonists. Inclusion […]
LOOP Trial: ILR for AFib to Prevent Stroke
2021 LOOP TRIAL Implantable loop recorder detection of atrial fibrillation to prevent stroke open-label, randomized controlled trial Objective: To assess the efficacy and safety of continuous monitoring for atrial fibrillation (AF) with an implantable loop recorder (ILR) versus usual care among patients at high risk for stroke without known history of AF 6004 Patients Inclusion […]
MR CLEAN-NO IV Trial Summary: IV Alteplase before Endovascular Therapy in Stroke
2021 MR CLEAN-NO IV TRIAL M 2021 A Randomized Trial of Intravenous Alteplase before Endovascular Treatment(EVT) for Stroke investigator-initiated, international, multicenter, prospective, randomized, open-label trial ” d Objective: To determine whether EVT alone would be more effective, or noninferior, as compared with intravenous alteplase followed by EVT in European patients with acute ischemic stroke due […]
DIRECT MT Trial Summary: Thrombectomy with or without Alteplase in Stroke
2020 DIRECT-MT TRIAL: Endovascular thrombectomy with or without intravenous alteplase in acute stroke Investigator-initiated, multicentre, prospective, randomised, open-label trial Objective: To evaluate endovascular thrombectomy with or without intravenous alteplase in patients with acute ischemic stroke 656 patients Participants > 18 years with occlusion of the intracranial segment of the ICA and/or of the 1st or […]