mechanical ventilation

ACURASYS Trial Summary: NM blockers in ARDS

2010 ACURASYS TRIAL Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome Multicenter, double-blinded, placebo-controlled trial Objective: To assess if administration of cisatracurium improve survival when compared to placebo in ICU patients undergoing mechanical ventilation for early severe ARDS 340 patients … Read More

NONSEDA Trial Summary: Sedation in Critically Ill Intubated Patients

2020 NONSEDA TRIAL M Nonsedation or light sedation in critically ill, mechanically ventilated patients Investigator-initiated, randomised, clinical, parallel-group, multinational, superiority trial . a 5 Objective: To assess whether in critically ill, mechanically ventilated patients, does a strategy of no sedation, … Read More

PEPTIC Trial Summary: PPI vs. H2 blockers for Stress Ulcers in Intubated Patients

2020 PEPTIC TRIAL Effect of stress ulcer prophylaxis with Proton pump inhibitors vs Histamine-2 receptor blockers on in-hospital mortality among ICU patients receiving invasive mechanical ventilation Pragmatic, open-label, cluster randomised crossover design trial Objective: To compare in-hospital mortality rates using … Read More

RECONNECT Trial Summary: Mechanical Ventilation After Successful Spontaneous Breathing Trial

2017 RECONNECT TRIAL Reconnection to mechanical ventilation (MV) for 1h after a successful spontaneous breathing trial (SBT) reduces reintubation in critically ill patients. Parallel, two-arm, prospective randomised controlled trial Objective: To evaluate the reduction in need for reintubation in critically … Read More