VITAMINS Trial Summary The VITAMINS trial aimed to determine whether the combination of vitamin C, hydrocortisone, and thiamine is more effective than hydrocortisone alone in expediting the resolution of septic shock. The trial included 216 patients with septic shock and compared the duration of time alive and free of vasopressor administration over 7 days between […]
Tag: vasopressor
VITAMINS Trial: Vitamin C, hydrocortisone, and thiamine in Septic Shock
2021 2021 VITAMINS TRIAL M Effect of Vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock Open label, multi-centre, randomized, phase IIb clinical trial Objective: To investigate whether treatment with Vitamin C, hydrocortisone & thiamine (intervention) lead to a more rapid resolution of […]
MIDAS Trial Summary: Midodrine for Vasopressor Weaning
2020 MIDAS TRIAL: Effect of midodrine versus placebo on time to vasopressor discontinuation in patients with persistent hypotension in the intensive care unit Multi-centre, randomised, double-blind, placebo-controlled trial Objective: To investigate whether the administration of midodrine, an oral al-adrenergic agonist, as adjunct to standard treatment shortens the duration of intravenous vasopressor requirement 132 Hypotensive patients […]