ENRICH Trial: Minimally Invasive Removal of ICH

Year: 2024 Title: ENRICH TRIAL Subtitle: Trial of Early Minimally Invasive Removal of Intracerebral Hemorrhage Type of Trial: A multicenter, randomized, adaptive clinical trial Objective: To compare standard medical management to early (<24 hours) surgical hematoma evacuation using minimally invasive … Read More

RESCUE-ASDH: Craniotomy vs. Decompressive Craniectomy

The RESCUE-ASDH Trial: Craniotomy vs. Decompressive Craniectomy The RESCUE-ASDH Trial, conducted in 2023, was a multicenter, randomized, controlled trial that played a crucial role in understanding the management of acute subdural hematoma (ASDH), a severe brain injury. Objective of the … Read More

INTERACT3 Trial: ICU care bundle in acute ICH

INTERACT3 Trial Summary Background: Methods: Findings: Primary Outcome: Interpretation: Trial Information: Key Takeaways: Source

TICH-2 Trial Summary: Tranexamic acid for IntraCerebral Haemorrhage

2018 TICH-2 TRIAL Tranexamic acid for hyperacute primary intracerebral haemorrhage Double blind, randomised, placebo-controlled, phase 3 superiority trial Objective: To assess whether tranexamic acid reduces haematoma expansion and improves outcome in adults with stroke due to intracerebral haemorrhage 3 2325 … Read More

COBI Trial Summary: Hypertonic Saline in Traumatic Brain Injury

2021 COBI TRIAL M Effect of continuous infusion of hypertonic saline vs standard care on 6-month neurological outcomes in patients with traumatic brain injury multicenter, parallel-group, open-label, randomized clinical trial Objective: To assess whether continuous infusion of 20% hypertonic saline … Read More

Beta Blockers in Traumatic Brain Injury Trial Summary

2020 BETA-BLOCKER THERAPY IN TBI Beta-Blocker Therapy in Severe Traumatic Brain Injury (TBI) Single-center,non-blinded,randomized controlled trial d d Objective: To examine the effect of beta-blockers on outcomes in TBI patients. 154 patients Patients > 18 years with: -blunt head trauma … Read More