WOMAN Trial: The Use of Tranexamic Acid in Reducing Death Due to Post-Partum Haemorrhage Post-partum haemorrhage (PPH) is a leading cause of maternal mortality worldwide. The administration of tranexamic acid has been shown to decrease bleeding-related deaths in trauma patients. A recent trial aimed to assess the impact of early tranexamic acid administration on death, […]
Tag: tranexamic acid
TICH-2 Trial Summary: Tranexamic acid for IntraCerebral Haemorrhage
2018 TICH-2 TRIAL Tranexamic acid for hyperacute primary intracerebral haemorrhage Double blind, randomised, placebo-controlled, phase 3 superiority trial Objective: To assess whether tranexamic acid reduces haematoma expansion and improves outcome in adults with stroke due to intracerebral haemorrhage 3 2325 Inclusion criteria: Adult patients with Intracerebral haemorrhage admitted to hospital within 8 hours of stroke […]
WOMAN Trail Summary: Early tranexamic acid in post-partum hemorrhage
2018 WOMAN TRIAL Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage Randomised, double-blind, placebo-controlled trial Objective: To determine whether early administration of tranexamic acid reduces death from bleeding in women with post-partum haemorrhage as compared with placebo 5 20,060 Inclusion criteria: Women aged 216 years with […]
ATACAS Trial Summary: Tranexamic Acid in Coronary Artery Surgery
2017 ATACAS TRIAL: Tranexamic Acid in patients undergoing coronary artery surgery Multicenter,2×2 factorial design, double-blind, randomized controlled trial Objective: To evaluate death risk and thrombotic complications with TXA among at-risk patients undergoing coronary artery surgery. 4662 Inclusion criteria: Patients >18 years of age undergoing elective coronary artery surgery either on or off pump & at […]
POISE-3 Trial Summary: Tranexamic Acid in Noncardiac Surgery
2022 POISE-3 TRIAL МІ Tranexamic Acid in Patients Undergoing Noncardiac Surgery International, randomized, controlled trial Objective: In patients undergoing noncardiac surgery who are at risk for bleeding and CV events, does tranexamic acid lowers incidence of major bleeding when compared to placebo and is it noninferior to placebo with respect to the incidence of major […]