WATERFALL Trial Summary The WATERFALL trial aimed to evaluate the effectiveness and safety of early aggressive hydration in the management of acute pancreatitis. While early aggressive hydration is a commonly recommended approach, limited evidence exists to support this practice. Conducted at 18 centers, the trial randomly assigned patients presenting with acute pancreatitis to receive either […]
Category: Gastroenterology
WATERFALL Trial Summary: Fluids in Pancreatitis
2022 WATERFALL TRIAL Aggressive or moderate fluid resuscitation in acute pancreatitis multicenter, open-label, parallel-group, superiority, randomized controlled trial Objective: To evaluate the safety & efficacy of aggressive fluid resuscitation as compared with moderate fluid resuscitation for the management of acute pancreatitis 249 patients Patients ≥18 yrs with acute pancreatitis (Revised Atlanta Classification-meeting 2 of the […]
Albumin in Cirrhosis and SBP Clinical Trial
Effect of Intravenous Albumin on Renal Impairment and Mortality in Patients with Cirrhosis and Spontaneous Bacterial Peritonitis Multi-center, open-label (analyst-blinded), randomised controlled trial Objective: To assess use of IV albumin for reducing renal impairment and mortality when compared to antibiotics alone in patients with cirrhosis and SBP. 126 Patients cirrhosis and SBP (PMN cell count […]
NORDICC Trial Summary: Colonoscopy for Colorectal Cancer Screening
2022 NORDICC TRIAL Effect of colonoscopy screening on risks of colorectal cancer and related death pragmatic, multicenter, randomized controlled trial Objective: To investigate the effects of population-based colonoscopy screening on the risks of colorectal cancer and related death at 10 years 84,585 patients Inclusion criteria: Presumptively healthy men and women 55 to 64 years of […]
SURMOUNT-1 Trial: Tirzepatide for Weight Loss in Obesity
2022 SURMOUNT-1 TRIAL M Tirze patide Once Weekly for the Treatment of Obesity Phase 3 double-blind, randomized, controlled trial Objective: To assess the efficacy and safety of tirzepatide, a novel glucose-dependent insulinotropic polypeptide and GLP-1 agonist, in treatment of obesity 2539 Adults with a body-mass index (BMI) of 30 or more, or 27 or more […]
PEPTIC Trial Summary: PPI vs. H2 blockers for Stress Ulcers in Intubated Patients
2020 PEPTIC TRIAL Effect of stress ulcer prophylaxis with Proton pump inhibitors vs Histamine-2 receptor blockers on in-hospital mortality among ICU patients receiving invasive mechanical ventilation Pragmatic, open-label, cluster randomised crossover design trial Objective: To compare in-hospital mortality rates using PPIs vs Histamine-2 receptor blockers (H2RBs) for stress ulcer prophylaxis. 26828 Inclusion criteria: Participants 18 […]