GZGI TRIAL Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity Phase 2, randomized, double-blind, placebo-controlled trial Objective:To assess the efficacy and safety of orforglipron, an oral non-peptide GLP-1 receptor agonist, for weight reduction in adults with obesity, or … Read More
Gastroenterology
ASSERT Trial: Odevixibat in Alagille Syndrome
ASSERT Trial Highlights Efficacy of Odevixibat in Alagille Syndrome In a significant stride towards better management of Alagille Syndrome, the ASSERT trial has recently showcased promising results for the ileal bile acid transporter inhibitor, Odevixibat. This phase 3, double-blind, randomized, … Read More
MAESTRO-NASH Trial: Resmetirom for NASH
Objective: To determine if 80 or 100 mg of Resmetirom compared with placebo resolves NASH and/or reduces fibrosis on liver biopsy and prevents progression to cirrhosis and/or advanced liver disease. Inclusion Criteria: Exclusion Criteria: Participants: 966 Patients Treatment Groups: Primary … Read More
ELATIVE Trial: Elafibranor in PBC
Title: ELATIVE Trial: A Landmark Study on Elafibranor’s Efficacy in Primary Biliary Cholangitis Introduction:The medical community has taken a significant step forward with the recent ELATIVE Trial, a study that rigorously evaluates the efficacy and safety of Elafibranor in patients … Read More
WATERFALL Trial Summary: Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis
WATERFALL Trial Summary The WATERFALL trial aimed to evaluate the effectiveness and safety of early aggressive hydration in the management of acute pancreatitis. While early aggressive hydration is a commonly recommended approach, limited evidence exists to support this practice. Conducted … Read More
WATERFALL Trial Summary: Fluids in Pancreatitis
2022 WATERFALL TRIAL Aggressive or moderate fluid resuscitation in acute pancreatitis multicenter, open-label, parallel-group, superiority, randomized controlled trial Objective: To evaluate the safety & efficacy of aggressive fluid resuscitation as compared with moderate fluid resuscitation for the management of acute … Read More
Albumin in Cirrhosis and SBP Clinical Trial
Effect of Intravenous Albumin on Renal Impairment and Mortality in Patients with Cirrhosis and Spontaneous Bacterial Peritonitis Multi-center, open-label (analyst-blinded), randomised controlled trial Objective: To assess use of IV albumin for reducing renal impairment and mortality when compared to antibiotics … Read More
NORDICC Trial Summary: Colonoscopy for Colorectal Cancer Screening
2022 NORDICC TRIAL Effect of colonoscopy screening on risks of colorectal cancer and related death pragmatic, multicenter, randomized controlled trial Objective: To investigate the effects of population-based colonoscopy screening on the risks of colorectal cancer and related death at 10 … Read More
SURMOUNT-1 Trial: Tirzepatide for Weight Loss in Obesity
2022 SURMOUNT-1 TRIAL M Tirze patide Once Weekly for the Treatment of Obesity Phase 3 double-blind, randomized, controlled trial Objective: To assess the efficacy and safety of tirzepatide, a novel glucose-dependent insulinotropic polypeptide and GLP-1 agonist, in treatment of obesity … Read More
PEPTIC Trial Summary: PPI vs. H2 blockers for Stress Ulcers in Intubated Patients
2020 PEPTIC TRIAL Effect of stress ulcer prophylaxis with Proton pump inhibitors vs Histamine-2 receptor blockers on in-hospital mortality among ICU patients receiving invasive mechanical ventilation Pragmatic, open-label, cluster randomised crossover design trial Objective: To compare in-hospital mortality rates using … Read More