Category: Gastroenterology

WATERFALL Trial Summary: Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis

WATERFALL Trial Summary The WATERFALL trial aimed to evaluate the effectiveness and safety of early aggressive hydration in the management of acute pancreatitis. While early aggressive hydration is a commonly recommended approach, limited evidence exists to support this practice. Conducted at 18 centers, the trial randomly assigned patients presenting with acute pancreatitis to receive either […]

WATERFALL Trial Summary: Fluids in Pancreatitis

2022 WATERFALL TRIAL Aggressive or moderate fluid resuscitation in acute pancreatitis multicenter, open-label, parallel-group, superiority, randomized controlled trial Objective: To evaluate the safety & efficacy of aggressive fluid resuscitation as compared with moderate fluid resuscitation for the management of acute pancreatitis 249 patients Patients ≥18 yrs with acute pancreatitis (Revised Atlanta Classification-meeting 2 of the […]

Albumin in Cirrhosis and SBP Clinical Trial

Effect of Intravenous Albumin on Renal Impairment and Mortality in Patients with Cirrhosis and Spontaneous Bacterial Peritonitis Multi-center, open-label (analyst-blinded), randomised controlled trial Objective: To assess use of IV albumin for reducing renal impairment and mortality when compared to antibiotics alone in patients with cirrhosis and SBP. 126 Patients cirrhosis and SBP (PMN cell count […]

NORDICC Trial Summary: Colonoscopy for Colorectal Cancer Screening

2022 NORDICC TRIAL Effect of colonoscopy screening on risks of colorectal cancer and related death pragmatic, multicenter, randomized controlled trial Objective: To investigate the effects of population-based colonoscopy screening on the risks of colorectal cancer and related death at 10 years 84,585 patients Inclusion criteria: Presumptively healthy men and women 55 to 64 years of […]

PEPTIC Trial Summary: PPI vs. H2 blockers for Stress Ulcers in Intubated Patients

2020 PEPTIC TRIAL Effect of stress ulcer prophylaxis with Proton pump inhibitors vs Histamine-2 receptor blockers on in-hospital mortality among ICU patients receiving invasive mechanical ventilation Pragmatic, open-label, cluster randomised crossover design trial Objective: To compare in-hospital mortality rates using PPIs vs Histamine-2 receptor blockers (H2RBs) for stress ulcer prophylaxis. 26828 Inclusion criteria: Participants 18 […]